D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
- CAS NO.：103733-65-9
- Empirical Formula: C10H11NO2
- Molecular Weight: 177.2
- MDL number: MFCD00144038
- EINECS: 266-580-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-12 11:00:47
What is D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid?
Description
D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid ((3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid) is a magnetic, neutral compound. It is used as a pharmacological study to investigate the reaction mechanism and kinetics of the deuteration process. The asymmetric synthesis of D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid has been investigated using vinylene chloride and hydantoin as reactants. There are various parameters that affect the kinetics of this reaction such as solvent type and temperature. The nitric oxide synthase inhibitor activity of D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid has been studied in vitro. Results have shown that it inhibits nitric oxide synthase by binding to the heme iron of the enzyme and preventing the conversion of arginine
Chemical properties
White solid
The Uses of D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
(R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
Definition
ChEBI: D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid is a member of isoquinolines.
Properties of D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Melting point: | 320-323 °C (decomp) |
| Boiling point: | 372.0±42.0 °C(Predicted) |
| Density | 1.225±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Aqueous Acid (Slightly), Aqueous Base (Sparingly, Sonicated) |
| pka | 2.21±0.20(Predicted) |
| form | Crystalline Powder |
| color | White |
| InChI | InChI=1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m1/s1 |
| CAS DataBase Reference | 103733-65-9(CAS DataBase Reference) |
Safety information for D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for D-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
| InChIKey | BWKMGYQJPOAASG-SECBINFHSA-N |
| SMILES | C1C2=C(C=CC=C2)C[C@H](C(O)=O)N1 |
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