1,2,3,4-TETRAHYDROISOQUINOLINE
- CAS NO.:91-21-4
- Empirical Formula: C9H11N
- Molecular Weight: 133.19
- MDL number: MFCD00006896
- EINECS: 202-050-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:43
What is 1,2,3,4-TETRAHYDROISOQUINOLINE?
Chemical properties
clear yellow to brown liquid
The Uses of 1,2,3,4-TETRAHYDROISOQUINOLINE
1,2,3,4-Tetrahydroisoquinoline is used as a reagent in the preparation of 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides as antiproliferative tubulin inhibitors.
Definition
ChEBI: 1,2,3,4-tetrahydroisoquinoline is a member of isoquinolines.
Synthesis Reference(s)
The Journal of Organic Chemistry, 40, p. 1191, 1975 DOI: 10.1021/jo00897a001
Tetrahedron Letters, 26, p. 4633, 1985 DOI: 10.1016/S0040-4039(00)98771-9
Properties of 1,2,3,4-TETRAHYDROISOQUINOLINE
Melting point: | −30 °C(lit.) |
Boiling point: | 232-233 °C(lit.) |
Density | 1.064 g/mL at 25 °C(lit.) |
vapor pressure | 3.33-97.9Pa at 20-58.5℃ |
refractive index | n |
Flash point: | 210 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | 20g/l |
form | Liquid |
pka | 9.66±0.20(Predicted) |
color | Clear yellow to brown |
Water Solubility | Soluble in water at 20°C 20g/L. |
BRN | 116156 |
CAS DataBase Reference | 91-21-4(CAS DataBase Reference) |
EPA Substance Registry System | Isoquinoline, 1,2,3,4-tetrahydro- (91-21-4) |
Safety information for 1,2,3,4-TETRAHYDROISOQUINOLINE
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H310:Acute toxicity,dermal H314:Skin corrosion/irritation H332:Acute toxicity,inhalation H371:Specific target organ toxicity, single exposure H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,2,3,4-TETRAHYDROISOQUINOLINE
InChIKey | UWYZHKAOTLEWKK-UHFFFAOYSA-N |
New Products
Tubulysin D Tubulysin I (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin C Tubulysin H Tubulysin M 3,3-Difluoropyrrolidine 4-IODOTETRAHYDRO-2H-PYRAN 4,4-DIFLUOROCYCLOHEXANAMINE 3-FLUOROPYRROLIDINE HYDROCHLORIDE 5-Methyl-1-indanone CYCLOBUTYLAMINE HYDROCHLORIDE 5-Nitrobarbituric acid N-(2-methoxy-5-nitrophenyl)acetamide N-[2-(Acetylthio)-1-oxobutyl]glycine ethyl ester 4-chloro-2-hydroxy-5-nitropyridine 5-Bromo-2-chloroisonicotinic acid methyl 2-bromobenzoate 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid HYDROCORTISONE EP IMPURITY G HALOPERIDOL HYDROBROMIDE Quetiapine EP Impurity J Quetiapine Triether AlcoholRelated products of tetrahydrofuran
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1,2-DIMETHYL-6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
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2-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)-5-(TRIFLUOROMETHYL)ANILINE
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