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HomeProduct name listCYTOCHALASIN E

CYTOCHALASIN E

  • CAS NO.:36011-19-5
  • Empirical Formula: C28H33NO7
  • Molecular Weight: 495.56
  • MDL number: MFCD00005178
  • EINECS: 252-835-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
CYTOCHALASIN E Structural

What is CYTOCHALASIN E?

Description

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B which potently and selectively inhibits the growth of endothelial cells (IC50 < 1 nM), impairing angiogenesis and tumor growth. This cytochalasin does not inhibit glucose transport or HIV-1 protease activity.

Chemical properties

white powder

The Uses of CYTOCHALASIN E

Cytochalasin E is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins, resulting in pronounced morphogenic changes in animals and plants. Despite the common mode of action, there is evidence that individual members display diverse selectivity. Specifically, cytochalasin E acts as an angiogenesis inhibitor and, unlike other cytochalasins, does not inhibit glucose transport.

The Uses of CYTOCHALASIN E

Cytochalasin E is a fungal metabolite which has been shown to exhibit antimicrobial and antibacterial effects. Cytochalasin E is a microfilament inhibitor enhancing the low-affinity Fc epsilon receptor (CD23) expression.

The Uses of CYTOCHALASIN E

Cytochalasin E has been used as:

  • a toxin to study its effects on avocado plants
  • a component of the incubating medium in feline junctional adhesion molecule 1 (fJAM-1) expression assay
  • an inhibitor of actin polymerization to study its effects on mitochondria uptake by mice endothelial cells

What are the applications of Application

Cytochalasin E, Aspergillus clavatus is a fungal toxin used in actin polymerization and cytological research

Definition

ChEBI: A natural product found in Arthrinium sacchari.

Biochem/physiol Actions

Cytochalasin E is an epoxide that exhibits anti-proliferative activity in endothelial cells in vitro. It also participates in inhibiting tumor growth and angiogenesis in vivo. Cytochalasin E also possesses antimicrobial and antiviral properties.

Properties of CYTOCHALASIN E

Melting point: 206 °C
Boiling point: 587.59°C (rough estimate)
Density  1.2415 (rough estimate)
refractive index  1.6290 (estimate)
storage temp.  -20°C
solubility  DMF: 11 mg/ml; DMF:PBS (pH7.2) (1:30): 0.03 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml
form  White solid.
pka 11.22±0.70(Predicted)
color  White to off-white
BRN  1096975

Safety information for CYTOCHALASIN E

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H300:Acute toxicity,oral
H310:Acute toxicity,dermal
H330:Acute toxicity,inhalation
H361:Reproductive toxicity
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P284:Wear respiratory protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350:IF ON SKIN: Gently wash with plenty of soap and water.

Computed Descriptors for CYTOCHALASIN E

Related products of tetrahydrofuran

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