CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG
Synonym(s):Laminin Nonapeptide - CAS 110590-60-8 - Calbiochem
- CAS NO.:110590-60-8
- Empirical Formula: C40H62N12O14S
- Molecular Weight: 967.06
- MDL number: MFCD00076474
- EINECS: 202-005-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG?
The Uses of CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG
Derived from residues 925-933 of human laminin B1, this peptide binds the laminin receptor, Inhibits experimental metastasis. find useful for product applications. And it is also used in Western Blot, Blocking Peptides, Dot Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Flow Cytomety, Cell Culture.
Biological Activity
laminin (925-933) is a peptide(cys-asp-pro-gly-tyr-ile-gly-ser-arg) derived from residues 925-933 of the laminin b1 chain that binds to the laminin receptor.laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. they have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly a, b1, and b2, respectively)the laminin beta 1 chain has 7 structurally distinct domains, which it shares with other beta chain isomers. laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from engelbreth-holm-swarm (ehs) tumor. a sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.figure1 structure of lamininfigure2 formula of lamininb1 (925-933)
References
1.Ikonen J, Pikkarainen T, Savolainen ER, Tryggvason K (Feb 1989). "A Hpa I polymorphism in the human laminin B1 chain gene on 7q22". Nucleic Acids Res 17 (1): 473.2.Roche KB, Moore JW, Surana RB, Wilson BE (May 1989). "Aortic root dilatation associated with partial trisomy 7(q31.2----qter)". Pediatr Cardiol 10 (1): 53–5.3.Bonneau D, Huret JL, Godeau G, Couet D, Putterman M, Tanzer J, Babin P, Larregue M (Sep 1991). "Recurrent ctb(7)(q31.3) and possible laminin involvement in a neonatal cutis laxa with a Marfan phenotype". Hum Genet 87 (3): 317–9.
Properties of CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG
Density | 1.54±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | Soluble in 5% acetic acid. |
form | White to off-white lyophilized solid |
pka | 3.23±0.10(Predicted) |
Safety information for CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG
Computed Descriptors for CYS-ASP-PRO-GLY-TYR-ILE-GLY-SER-ARG
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
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