Curcumol

Synonym(s):(−)-Curcumol;(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol

CAS NO.：4871-97-0
Empirical Formula: C15H24O2
Molecular Weight: 236.35
MDL number: MFCD00272163
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Curcumol?

Definition

ChEBI: Curcumol is a sesquiterpenoid.

Biological Activity

Curcumol is a biologically active sesquiterpene with many pharmacological activities such as anticancer, antimicrobial, antifungal, antiviral and anti-inflammatory. It efficiently induces apoptosis in many cancer cells by targeting key signaling pathways such as MAPK/ERK, PI3K/Akt and NF-κB, which are often dysregulated in several cancers.

in vitro

Curcumol ((-)-Curcumol) is the major component extracted from root of Rhizoma Curcumae . Curcumol exerts anticancer effect in cholangiocarcinoma cells via down-regulating CDKL3. It induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. It suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways.

Properties of Curcumol

Melting point:	141.0 to 145.0 °C
Boiling point:	334.5±42.0 °C(Predicted)
Density	1.06±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO:55.67(Max Conc. mg/mL);235.54(Max Conc. mM) DMF:20.0(Max Conc. mg/mL);84.62(Max Conc. mM) Ethanol:28.5(Max Conc. mg/mL);120.58(Max Conc. mM)
form	Solid
form	neat
pka	13.02±0.60(Predicted)
color	White to Light yellow
CAS DataBase Reference	4871-97-0