BAVACHIN

Synonym(s):(2S)-2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4′,7-Dihydroxy 6-(3-methyl 2-butenyl)flavanone;Corylifolin

CAS NO.：19879-32-4
Empirical Formula: C20H20O4
Molecular Weight: 324.37
MDL number: MFCD11617359
SAFETY DATA SHEET (SDS)
Update Date: 2023-08-17 18:11:45

What is BAVACHIN?

Description

Bavachin is a flavonoid first isolated from seeds of P. corylifolia. It is a phytoestrogen that activates the estrogen receptors ERα and ERβ (EC₅₀s = 320 and 680 nM, respectively). Through this action, bavachin stimulates osteoblast proliferation and differentiation and prevents bone loss following ovariectomy in rats. Bavachin less potently inhibits acyl-coenzyme A:cholesterol acyltransferase (IC₅₀ = 86 μM).

The Uses of BAVACHIN

Bavachin has therapeutic potential for type 2 diabetes by activating insulin signaling pathways. Also, it has anabolic and potent anticatabolic biological effects on chondrocytes. Strong inhibitor of human UDP-glucuronosyltransferase (UGT1A1)

What are the applications of Application

Bavachin is a weak antioxidant that stimulates bone formation

References

[1] choi j h, rho m c, lee s w, et al. bavachin and isobavachalcone, acyl-coenzyme a: cholesterol acyltransferase inhibitors from psoralea corylifolia[j]. archives of pharmacal research, 2008, 31(11): 1419-1423.
[2] park j, kim d h, ahn h n, et al. activation of estrogen receptor by bavachin from psoralea corylifolia[j]. biomolecules & therapeutics, 2012, 20(2): 183-188.
[3] lee h, li h, noh m, et al. bavachin from psoralea corylifolia improves insulin-dependent glucose uptake through insulin signaling and ampk activation in 3t3-l1 adipocytes[j]. international journal of molecular sciences, 2016, 17(4): 527.

Properties of BAVACHIN

Boiling point:	558.3±50.0 °C(Predicted)
Density	1.244
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	≤20mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form	crystalline solid
pka	8.27±0.40(Predicted)
color	White
CAS DataBase Reference	19879-32-4

Safety information for BAVACHIN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.