Collagen

Chemical properties

type V

The Uses of Collagen

for collagenase binding

The Uses of Collagen

inhibit carcinogenesis

The Uses of Collagen

Collagen, bovine achilles tendon is suitable for cell adhesion in tissue culture, as well as gel formation, platelet aggregation, and as a substrate for collagenase. It is also been used as cell culture substratum, adhesion. It is also used as an attachment factor for primary cultures of epithelioid cells.

Definition

Protein of connective tissues that comprises approximately 30% of total body protein from which body tissues are formed.

General Description

Collagen type I is a component of skin, bone, tendon, and other fibrous connective tissues. It consists of repeating triplet amino acids glycine, proline and hydroxyproline. Collagen is a left handed helix with three polypeptide chains. It is a component of extracellular matrix and as close to 28 types are present in bovine.

Biochem/physiol Actions

Collagen is essential for the mechanical integrity of tendons and bone. Rat tail tendon collagen is used in tissue engineering especially in the generation of 3-D scaffolds based gels. It has low antigenicity and is compatible with human gingival fibroblasts and human oral keratinocytes.