Clobetasol

Chemical properties

White to Off-White Solid

Originator

Dermovate,Glaxo,UK,1973

The Uses of Clobetasol

Clobetasol (Clobetasol Propionate EP Impurity G) is a topical corticosteroid. Glucocorticoid; anti-inflammatory.

The Uses of Clobetasol

Atorvastatin Intermediate

Background

Clobetasol is under investigation for the treatment of Scleroderma. Clobetasol has been investigated for the prevention of Psoriasis and Cutaneous Atrophy Due to Corticosteroids.

What are the applications of Application

Clobetasol is a topical corticosteroid, glucocorticoid, and antiinflammatory

Definition

ChEBI: A 3-oxo-Delta1,Delta4-steroid that is 16beta-methylpregna-1,4-diene-3,20-dione bearing hydroxy groups at the 11beta and 17alpha posit ons, fluorine at position 9, and a chlorine substituent at position 21. It is used as its 17alpha-propionate ester to treat various skin disorders, including exzema and psoriasis.

Manufacturing Process

A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.

brand name

Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).

Therapeutic Function

Corticosteroid, Antiinflammatory

Metabolism

Not Available