9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
- CAS NO.：981-34-0
- Empirical Formula: C22H28O5
- Molecular Weight: 372.45
- MDL number: MFCD09038712
- EINECS: 213-563-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-03 16:33:47
What is 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione ?
Description
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.
Chemical properties
Off-White Solid
The Uses of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Metabolite of Beclometasone (131000)
The Uses of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.
What are the applications of Application
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Beclometasone
Preparation
Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
Properties of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
| Melting point: | 210-220 ºC |
| Boiling point: | 564.9±50.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| vapor pressure | 0-357.304Pa at 25℃ |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated) |
| form | Solid |
| pka | 12.56±0.70(Predicted) |
| color | White to Light Beige |
Safety information for 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Computed Descriptors for 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
| InChIKey | GBDXNHBVYAMODG-OBDZOPJXNA-N |
| SMILES | C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r| |
Abamectin manufacturer
GLP Pharma Standards
SYNTHINK RESEARCH CHEMICALS
Molsyns Research
Allmpus Laboratories Pvt Ltd
New Products
Tubulysin E Tubulysin H Tubulysin D Tubulysin C Tubulysin B Potassium HMDS (1.0 M in THF) 4,4-DIFLUOROPIPERIDINE 2,2-Difluoropropanol 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate CYCLOBUTYLAMINE HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(2-Formylphenoxy) acetic acid (R)-1-Aminoindan Hydrochloride Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc BorateRelated products of tetrahydrofuran
You may like
-
981-34-0 Beclometasone Dipropionate EP Impurity R 98%View Details
981-34-0 -
981-34-0 98%View Details
981-34-0 -
Betamethasone EP Impurity E 98%View Details
981-34-0 -
Beclometasone Dipropionate EP Impurity-R 981-34-0 98%View Details
981-34-0 -
981-34-0 Betamethasone EP Impurity E 98%View Details
981-34-0 -
981-34-0 95.8View Details
981-34-0 -
981-34-0 BECLOMETASONE DIPROPIONATE EP IMPURITY R 98.89View Details
981-34-0 -
Beclomethasone Dipropionate Impurity 1 98% (HPLC) CAS 981-34-0View Details
981-34-0