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HomeProduct name list9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

  • CAS NO.:981-34-0
  • Empirical Formula: C22H28O5
  • Molecular Weight: 372.45
  • MDL number: MFCD09038712
  • EINECS: 213-563-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-11-03 16:33:47
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione  Structural

What is 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione ?

Description

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemical properties

Off-White Solid

The Uses of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Metabolite of Beclometasone (131000)

The Uses of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.

What are the applications of Application

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Beclometasone

Preparation

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Properties of 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Melting point: 210-220 ºC
Boiling point: 564.9±50.0 °C(Predicted)
Density  1.32±0.1 g/cm3(Predicted)
vapor pressure  0-357.304Pa at 25℃
storage temp.  Refrigerator
solubility  Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
form  Solid
pka 12.56±0.70(Predicted)
color  White to Light Beige

Safety information for 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Computed Descriptors for 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

InChIKey GBDXNHBVYAMODG-OBDZOPJXNA-N
SMILES C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|

Abamectin manufacturer

GLP Pharma Standards

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Phone:+91-9866074638
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product: Beclometasone Dipropionate EP Impurity-R 981-34-0 98%
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Molsyns Research

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Phone:+91-9586858886
Whatsapp: +91- 9586858886
product: 981-34-0 Betamethasone EP Impurity E 98%
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Allmpus Laboratories Pvt Ltd

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Phone:+91-9167862134
Whatsapp: +91-9167862134
product: 981-34-0 95.8
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