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HomeProduct name listClimbazole

Climbazole

Synonym(s):1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

  • CAS NO.:38083-17-9
  • Empirical Formula: C15H17ClN2O2
  • Molecular Weight: 292.76
  • MDL number: MFCD00055505
  • EINECS: 253-775-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Climbazole Structural

What is Climbazole?

Description

(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.

Chemical properties

White Solid

The Uses of Climbazole

Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

What are the applications of Application

Climbazole is a potent inducer and inhibitor of P450-dependent metabolizing enzymes

Definition

ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.

Hazard

Moderately toxic by ingestion. Low toxicity by skin contact.

Flammability and Explosibility

Non flammable

Side Effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.

Properties of Climbazole

Melting point: 96-100°C
Boiling point: 447.5±40.0 °C(Predicted)
Density  1.17±0.1 g/cm3(Predicted)
vapor pressure  0.001Pa at 25℃
refractive index  1.54
storage temp.  Inert atmosphere,Room Temperature
solubility  Insoluble in water
form  neat
pka 5.66±0.22(Predicted)
form  Solid
color  White to Almost white
Water Solubility  58mg/L at 25℃
BRN  618020
CAS DataBase Reference 38083-17-9(CAS DataBase Reference)

Safety information for Climbazole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H410:Hazardous to the aquatic environment, long-term hazard

Computed Descriptors for Climbazole

InChIKey OWEGWHBOCFMBLP-UHFFFAOYSA-N

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