Climbazole
Synonym(s):1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one
- CAS NO.:38083-17-9
- Empirical Formula: C15H17ClN2O2
- Molecular Weight: 292.76
- MDL number: MFCD00055505
- EINECS: 253-775-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is Climbazole?
Description
(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.
Chemical properties
White Solid
The Uses of Climbazole
Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
What are the applications of Application
Climbazole is a potent inducer and inhibitor of P450-dependent metabolizing enzymes
Definition
ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Hazard
Moderately toxic by ingestion. Low toxicity by skin contact.
Flammability and Explosibility
Non flammable
Side Effects
May cause localized irritation of the skin with symptoms including redness, rashes and itching.
Properties of Climbazole
Melting point: | 96-100°C |
Boiling point: | 447.5±40.0 °C(Predicted) |
Density | 1.17±0.1 g/cm3(Predicted) |
vapor pressure | 0.001Pa at 25℃ |
refractive index | 1.54 |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Insoluble in water |
form | neat |
pka | 5.66±0.22(Predicted) |
form | Solid |
color | White to Almost white |
Water Solubility | 58mg/L at 25℃ |
BRN | 618020 |
CAS DataBase Reference | 38083-17-9(CAS DataBase Reference) |
Safety information for Climbazole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard |
Computed Descriptors for Climbazole
InChIKey | OWEGWHBOCFMBLP-UHFFFAOYSA-N |
Abamectin manufacturer
Salicylates and Chemicals Pvt. Ltd.
Related products of tetrahydrofuran
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