Climbazole

Synonym(s):1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

CAS NO.：38083-17-9
Empirical Formula: C15H17ClN2O2
Molecular Weight: 292.76
MDL number: MFCD00055505
EINECS: 253-775-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-11 20:10:50

What is Climbazole?

Description

(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.

The Uses of Climbazole

Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

What are the applications of Application

Climbazole is a potent inducer and inhibitor of P450-dependent metabolizing enzymes

Properties of Climbazole

Melting point:	96-100°C
Boiling point:	447.5±40.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Insoluble in water
form	neat
color	White to Almost white
Water Solubility	58mg/L at 25℃

Safety information for Climbazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H410:Hazardous to the aquatic environment, long-term hazard