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HomeProduct name listCinobufotalin

Cinobufotalin

Synonym(s):14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate;5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate

Cinobufotalin Structural

What is Cinobufotalin?

Description

Cinobufacin is an indole-type total alkaloid extracted from the dried toad skin of Chinese toad, which has the functions of clearing away heat and detoxifying, reducing swelling and pain, promoting blood circulation and removing blood stasis, softening and dispelling knots.

What are the applications of Application

Cinobufotalin is a specific Na+/K+-ATPase inhibitor

What are the applications of Application

Cinobufacin can be used for a variety of middle and advanced tumors (lung cancer, breast cancer, cervical cancer, digestive system tumors such as primary liver cancer, gastric cancer, colon cancer, etc.), chronic hepatitis B, especially for chronic hepatitis B virus carriers. Especially prominent.

Side Effects

For individual patients, if the dosage is too large or the interval between two administrations is less than 6 to 8 hours, chills and fever may occur about 30 minutes after administration; a small number of patients have local irritation or phlebitis after long-term intravenous infusion, which will slow down the infusion rate. Very few patients may also appear urticaria, dermatitis and so on.

Properties of Cinobufotalin

Melting point: 259-262°
Boiling point: 627.3±55.0 °C(Predicted)
alpha  D20 +11°
Density  1.34±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml
pka 14.67±0.70(Predicted)
form  White to off-white solid.
color  White to off-white
CAS DataBase Reference 1108-68-5

Safety information for Cinobufotalin

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P262:Do not get in eyes, on skin, or on clothing.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Cinobufotalin

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