Cinnamamide
- CAS NO.:621-79-4
- Empirical Formula: C9H9NO
- Molecular Weight: 147.17
- MDL number: MFCD00008033
- EINECS: 210-707-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-17 21:30:02
What is Cinnamamide?
Chemical properties
OFF-WHITE TO BEIGE CRYSTALLINE POWDER
The Uses of Cinnamamide
Cinnamamide, a non-lethal repellent, deters feeding by a wide range of avian species.
Definition
ChEBI: The simplest member of the class of cinnamamides that consists of acrylamide bearing a phenyl substituent at the 3-position.
Biological Activity
Cinnamamide is an amide form of of trans-cinnamic acid and a metabolite of Streptomyces. Cinnamamide exhibits low cytotoxicity against BEL-7402 human hepatoma cells and HT-1080 fibrosarcoma cells and inhibits cell growth (IC50s = 1.94 and 1.29 mM, respectively). In vivo, cinnamamide (40 and 100 mg/kg, i.p.) reduces tumor weight in a mouse model of C26 murine colon carcinoma. Cinnamamide (75 and 150 mg/kg, i.p.) also reduces tumor weight in a mouse model of murine hepatoma 22 by 42% and 49%, respectively, without reducing body weight when delivered one or three days following tumor implantation. When presented with cinnamamide-treated food at a concentration of 0.8% w/w, house and wood mice food consumption is reduced to 32% and 17% of pretreatment levels, respectively, however, wood mouse consumption returns to pretrial levels by day two.
Properties of Cinnamamide
Melting point: | 148-150 °C(lit.) |
Boiling point: | 267.28°C (rough estimate) |
Density | 1.1135 (rough estimate) |
refractive index | 1.5450 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 15?+-.0.50(Predicted) |
form | Crystalline Powder |
color | Off-white to beige |
BRN | 2040577 |
CAS DataBase Reference | 621-79-4(CAS DataBase Reference) |
NIST Chemistry Reference | Benzylidene acetamide(621-79-4) |
EPA Substance Registry System | 2-Propenamide, 3-phenyl- (621-79-4) |
Safety information for Cinnamamide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. |
Computed Descriptors for Cinnamamide
InChIKey | APEJMQOBVMLION-VOTSOKGWSA-N |
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