Chorionic Gonadotropin
Synonym(s):HCG;Chorionic gonadotropin human;Chorionic Gonadotropin, Human Urine, Iodination Grade;hCG-β;beta chorionic gonadotropin
- CAS NO.:9002-61-3
- Empirical Formula: C17H28
- Molecular Weight: 232.40422
- MDL number: MFCD00130797
- EINECS: 232-660-2
- Update Date: 2024-10-17 18:18:11
What is Chorionic Gonadotropin?
Chemical properties
White or yellowish-white, amorphous powder.
The Uses of Chorionic Gonadotropin
Chorionic gonadotropin human has been used:
- to induce oocyte maturation in cultured follicles
- along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
- as medium component for fetal testes culture to aid steroidogenic responsiveness
The Uses of Chorionic Gonadotropin
Gonad-stimulating principle.
Production Methods
CG is produced in the chorion.
What are the applications of Application
Human chorionic gonadotropin (hCG) is a chemical produced by the trophoblast tissue, which is usually present in the early embryo and will eventually become part of the placenta. Measuring hCG levels helps to identify normal, pathological and miscarried pregnancies. Measuring hCG is also beneficial for many cancers including choriocarcinoma and extrauterine malignancies.
brand name
A.P.L. (Ferring Pharmaceuticals); Follutein (Bristol-Myers Squibb); Pregnyl (Organon).
General Description
Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.
Biochem/physiol Actions
Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.
Clinical Use
Choriogonadotropin alfa is obtained by rDNA technology and is biologically and chemically identical to hCG of natural origin. It is used, like hCG of natural origin, for inducing ovulation in women with anovulatory infertility. Following proper pretreatment with a GnRH antagonist or superagonist to desensitize the pituitary, women participating in ART are treated with a folliclestimulating agent (e.g., menotropins) to effect the final maturation of the follicles within the ovaries. Ultrasonograms are used to determine proper follicle maturation before the administration of choriogonadotropin alfa to induce ovulation. A distinct advantage of this product is that it can be self-administered by the patient via SC injection.
Veterinary Drugs and Treatments
The veterinary product’s labeled indication is for “parenteral use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries.” It has been used for other purposes in several species; refer to the Dosage section for more information.
Properties of Chorionic Gonadotropin
storage temp. | 2-8°C |
solubility | H2O: soluble1ML/vial |
form | lyophilized powder |
color | White to off-white |
Safety information for Chorionic Gonadotropin
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H361:Reproductive toxicity |
Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for Chorionic Gonadotropin
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