Cholesteryl myristate
- CAS NO.：1989-52-2
- Empirical Formula: C41H72O2
- Molecular Weight: 597.01
- MDL number: MFCD00014256
- EINECS: 217-867-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:57
What is Cholesteryl myristate?
Description
Cholesteryl myristate is a cholesterol ester. Levels of cholesteryl myristate are increased in the serum, liver, and aorta in rabbits fed a high-cholesterol diet and positively correlate with development of non-alcoholic fatty liver disease (NAFLD). Plasma levels of cholesteryl myristate also positively correlate with the presence of unstable atherosclerotic plaques in coronary artery disease. Cholesterol myristate has been used in the composition of lipid nanoparticles as drug carrier systems for drugs with low water solubility.
The Uses of Cholesteryl myristate
Cholesteryl Myristate is a natural steroid present in traditional Chinese medicine or used in tribal medicine.
Definition
ChEBI: A cholesterol ester obtained by the formal condensation of the hydroxy group of cholesterol with the carboxy group of myristic acid.
Purification Methods
Crystallise the myristate ester from Me2CO, EtOH/EtOAc or EtOH/Et2O or n-pentanol. Purify it also by column chromatography on silica gel and eluting with MeOH then evaporating to dryness. Recrystallise it and finally, dry it in vacuo over P2O5 and store it at -20o. [Labarière et al. Analyt Chem 30 1466 1958, Malanik & Malat Anal Chim Acta 76 464 1975, Beilstein 6 III 2638].
Properties of Cholesteryl myristate
| Melting point: | 84 °C |
| Boiling point: | 589.77°C (rough estimate) |
| Density | 0.9309 (rough estimate) |
| refractive index | 1.5250 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Hexanes (Slightly) |
| form | A crystalline solid |
| color | White to off-white |
| CAS DataBase Reference | 1989-52-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Cholesteryl myristate(1989-52-2) |
| EPA Substance Registry System | Cholest-5-en-3-ol (3.beta.)-, tetradecanoate (1989-52-2) |
Safety information for Cholesteryl myristate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Cholesteryl myristate
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