chlorproethazine
- CAS NO.:84-01-5
- Empirical Formula: C19H23ClN2S
- Molecular Weight: 346.92
- MDL number: MFCD00867688
- EINECS: 201-510-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:43
What is chlorproethazine?
Chemical properties
Off-White Solid
Originator
Neuriplege, Genevrier ,France,1961
The Uses of chlorproethazine
MIchlorproethazine.
Definition
ChEBI: Chlorproethazine is a member of phenothiazines.
Manufacturing Process
2-Bromo-2'-(3''-dimethylaminopropyl)-amino-4'-chlorodiphenylsulfide (10 g) is dissolved in dimethylformamide (80 cc). To this solution is added potassium carbonate (5 g) and copper powder (0.4 g). It is then heated under reflux for 48 hours, cooled, and the insoluble matter filtered off. After washing with dimethylformamide (20 cc), the filtrate is taken up in distilled water (200cc). The base formed is extracted with ether (3 times with 50 cc), the ethereal solution is dried over sodium sulfate, the ether driven off on a water-bath and the residue distilled. In this way there is obtained 3-chloro-10-(3'- dimethylaminopropyl)-phenothiazine (6.4 g) which boils at 210 C to 225°C under 0.7 mm of mercury. The hydrochloride is made by the action of ethereal hydrogen chloride on the base dissolved in acetone; this hydrochloride melts at 180°C
Therapeutic Function
Muscle relaxant; Tranquilizer
Properties of chlorproethazine
Melting point: | 153-156°C |
Boiling point: | 211°C (rough estimate) |
Density | 1.1206 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | -20°C Freezer |
Safety information for chlorproethazine
Computed Descriptors for chlorproethazine
New Products
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