PROCHLORPERAZINE MALEATE

Synonym(s):Prochlorperazine dimaleate salt

CAS NO.：84-02-6
Empirical Formula: C28H32ClN3O8S
Molecular Weight: 606.09
MDL number: MFCD00069330
EINECS: 201-511-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 09:02:48

What is PROCHLORPERAZINE MALEATE?

Description

Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 μM for CME.1?Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2?A clinically useful antipsychotic agent3?with antimigraine4?and antiemetic activity5.

Chemical properties

Off-White Powder

The Uses of PROCHLORPERAZINE MALEATE

Antiemetic;Dopamine antagonist

The Uses of PROCHLORPERAZINE MALEATE

Antiemetic.

What are the applications of Application

Prochlorperazine, dimaleate is a D2 dopamine receptor antagonist

brand name

Compazine (GlaxoSmithKline).

General Description

Prochlorperazinemaleate, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazinemaleate (Compazine), is in the piperazine subgroupof the phenothiazines, characterized by high-milligramantipsychotic potency, a high prevalence of EPS, and lowsedative and autonomic effects. Prochlorperazine is more potenton a milligram basis than its alkylamino counterpart,chlorpromazine. Because of the high prevalence of EPS, however,it is used mainly for its antiemetic effect, not for its antipsychoticeffect.

Biological Activity

D 2 receptor antagonist. Also interacts with 5-HT 3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo .

Biochem/physiol Actions

Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic

References

References/Citations 1) Daniel?et al.?(2015),?Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic,?16?635 2) Chew?et al.?(2020),?Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell,?180?895 3) Hollister?et al.?(1969),?Clinical use of psychotherapeutic drugs: current status;?Clin. Pharmacol. Ther.,?10?170 4) Cook and Newberry (2018),?Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J.,?40?148 5) Van den Berg?et al.?(1996),?The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care,?24?538

Properties of PROCHLORPERAZINE MALEATE

Melting point:	1750C
storage temp.	2-8°C
solubility	Very slightly soluble in water and in ethanol (96 per cent).
form	neat
pka	pKa 8.1(H2O,t =24±1) (Uncertain)
color	White
λmax	313nm(MeOH)(lit.)
Merck	14,7761
Stability:	Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for PROCHLORPERAZINE MALEATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H336:Specific target organ toxicity,single exposure; Narcotic effects H362:Reproductive toxicity, effects on or via lactation
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P263:Avoid contact during pregnancy/while nursing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention.