Chlorozotocin
- CAS NO.:54749-90-5
- Empirical Formula: C9H16ClN3O7
- Molecular Weight: 313.69
- MDL number: MFCD00866505
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is Chlorozotocin?
Chemical properties
Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).
The Uses of Chlorozotocin
Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).
Definition
ChEBI: Chlorozotocin is an amino sugar.
Safety Profile
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NITROSAMINES.
Carcinogenicity
Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.
Properties of Chlorozotocin
Melting point: | 147-148° (dec with the evolution of gas); mp 140-141° (dec) |
Boiling point: | 119.3°C (rough estimate) |
Density | 1.6475 (rough estimate) |
refractive index | 1.6000 (estimate) |
pka | 9.08±0.46(Predicted) |
IARC | 2A (Vol. 50) 1990 |
EPA Substance Registry System | Chlorozotocin (54749-90-5) |
Safety information for Chlorozotocin
Computed Descriptors for Chlorozotocin
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