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HomeProduct name listChlorozotocin

Chlorozotocin

Chlorozotocin Structural

What is Chlorozotocin?

Chemical properties

Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).

The Uses of Chlorozotocin

Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).

Definition

ChEBI: Chlorozotocin is an amino sugar.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NITROSAMINES.

Carcinogenicity

Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.

Properties of Chlorozotocin

Melting point: 147-148° (dec with the evolution of gas); mp 140-141° (dec)
Boiling point: 119.3°C (rough estimate)
Density  1.6475 (rough estimate)
refractive index  1.6000 (estimate)
pka 9.08±0.46(Predicted)
IARC 2A (Vol. 50) 1990
EPA Substance Registry System Chlorozotocin (54749-90-5)

Safety information for Chlorozotocin

Computed Descriptors for Chlorozotocin

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