Chlorosulfonyl isocyanate

Synonym(s):N-Carbonylsulfamyl chloride;Chlorosulfonyl isocyanate;CSI

CAS NO.：1189-71-5
Empirical Formula: CClNO3S
Molecular Weight: 141.53
MDL number: MFCD00011608
EINECS: 214-715-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is Chlorosulfonyl isocyanate?

Chemical properties

Clear liquid, colourless

The Uses of Chlorosulfonyl isocyanate

Chlorosulfonyl isocyanate, a highly reactive chemical for chemical synthesis, is used as an intermediate used for production of antibiotics (Cefuroxime, penems), polymers as well as agrochemicals. Product Data Sheet

The Uses of Chlorosulfonyl isocyanate

Employed in a regio- and diastereoselective introduction of a protected amino group in a synthesis of chiral, polyhydroxylated piperidines. Generation of ureas from amino groups in a synthesis of benzimidazolones.

What are the applications of Application

Chlorosulfonyl isocyanate is a versatile reagent in organic synthesis

General Description

Chlorosulfonyl isocyanate reacts with hydrocarbon alkenes via stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams.

Properties of Chlorosulfonyl isocyanate

Melting point:	-44 °C (lit.)
Boiling point:	107 °C (lit.)
Density	1.626 g/mL at 25 °C (lit.)
vapor pressure	5.57 psi ( 20 °C)
refractive index	n20/D 1.447(lit.)
Flash point:	>110°C
storage temp.	2-8°C
solubility	Chloroform (Slightly, Heated)
form	Crystals, Crystalline Powder or Granules
color	White
Specific Gravity	1.626 (20℃)
Water Solubility	reacts violently exothermic
BRN	1237247
CAS DataBase Reference	1189-71-5(CAS DataBase Reference)
EPA Substance Registry System	Sulfuryl chloride isocyanate (1189-71-5)

Safety information for Chlorosulfonyl isocyanate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H314:Skin corrosion/irritation H317:Sensitisation, Skin H334:Sensitisation, respiratory
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.