Chlorodifluoroacetic acid ethyl ester

CAS NO.：383-62-0
Empirical Formula: C4H5ClF2O2
Molecular Weight: 158.53
MDL number: MFCD00013662
EINECS: 206-850-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-25 20:17:06

What is Chlorodifluoroacetic acid ethyl ester?

Chemical properties

clear colorless liquid

The Uses of Chlorodifluoroacetic acid ethyl ester

Ethyl chlorodifluoroacetate (ECDFA) may be used as a starting reagent in the synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols.

General Description

Ethyl chlorodifluoroacetate (ECDFA) undergoes Reformatskii reaction with various aldehydes in DMF. It reacts with phenylacetylene to afford ethyl α,α?difluoro-4-phenyl-3-butenoates.

Properties of Chlorodifluoroacetic acid ethyl ester

Boiling point:	96-97.5 °C (lit.)
Density	1.252 g/mL at 25 °C (lit.)
refractive index	n20/D 1.358(lit.)
Flash point:	65 °F
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Sparingly)
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	1.252
Sensitive	Moisture Sensitive
BRN	1761413
CAS DataBase Reference	383-62-0(CAS DataBase Reference)
EPA Substance Registry System	Acetic acid, chlorodifluoro-, ethyl ester (383-62-0)

Safety information for Chlorodifluoroacetic acid ethyl ester

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05
GHS Hazard Statements	H225:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.