Difluoroacetic acid
Synonym(s):DFA
- CAS NO.：381-73-7
- Empirical Formula: C2H2F2O2
- Molecular Weight: 96.03
- MDL number: MFCD00004220
- EINECS: 206-839-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is Difluoroacetic acid?
Chemical properties
clear colorless to light brown liquid
The Uses of Difluoroacetic acid
Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.
Definition
ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.
Flammability and Explosibility
Non flammable
Purification Methods
Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]
Properties of Difluoroacetic acid
| Melting point: | -1 °C (lit.) |
| Boiling point: | 132-134 °C (lit.) |
| Density | 1.526 g/mL at 25 °C (lit.) |
| vapor pressure | 11.7hPa at 25℃ |
| refractive index | n |
| Flash point: | 174 °F |
| storage temp. | 2-8°C |
| solubility | 540.54g/L in organic solvents at 20 ℃ |
| pka | pK1:1.33 (25°C) |
| form | Liquid |
| color | Clear colorless to light brown |
| Specific Gravity | 1.527 (20℃) |
| Water Solubility | 1000g/L at 37℃ |
| BRN | 1098588 |
| CAS DataBase Reference | 381-73-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Difluoroacetic acid(381-73-7) |
| EPA Substance Registry System | Acetic acid, difluoro- (381-73-7) |
Safety information for Difluoroacetic acid
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H332:Acute toxicity,inhalation H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Difluoroacetic acid
| InChIKey | PBWZKZYHONABLN-UHFFFAOYSA-N |
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