Chelerythrine
Synonym(s):1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride;Toddaline chloride
- CAS NO.:34316-15-9
- Empirical Formula: C21H18NO4+
- Molecular Weight: 348.37192
- MDL number: MFCD00270393
- EINECS: 251-930-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 18:01:06
![Chelerythrine Structural](https://img.chemicalbook.in/CAS/GIF/34316-15-9.gif)
What is Chelerythrine?
The Uses of Chelerythrine
Chelerythrine Chloride is a cell permeable protein kinase C (PKC) inhibitor.
Definition
ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae.
Biological Activity
Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis.
Purification Methods
Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent.
Properties of Chelerythrine
Melting point: | 195-205°C |
Boiling point: | 496.37°C (rough estimate) |
Density | 1.2985 (rough estimate) |
refractive index | 1.5614 (estimate) |
storage temp. | Desiccate at -20°C |
solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly, Sonicated), Methanol (Slightly |
form | Solid |
color | Light Yellow to Dark Orange |
Stability: | Hygroscopic |
CAS DataBase Reference | 34316-15-9(CAS DataBase Reference) |
Safety information for Chelerythrine
Signal word | Danger |
Pictogram(s) |
![]() Skull and Crossbones Acute Toxicity GHS06 ![]() Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H300:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Chelerythrine
New Products
1-Amino-1-cyclohexanecarboxylic acid Cycloleucine 6-Bromo-3-iodo-1-methyl-1H-indazole 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 7-Bromo-1H-indazole ELECTROLYTIC IRON POWDER 2-Methyl-2-phenylpropyl acetate 1-Aminocyclobutanecarboxylic acid 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride Decanonitrile tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate 4-Ethylbenzylamine Methyl 5-bromo-2-chloro-3-nitrobenzoate N-(5-Amino-2-methylphenyl)acetamide 2-Chloro-3-nitropyridine 5-Bromo-2,3-dimethoxypyridine methyl 6-chloro-2-(chloromethyl)nicotinate 2-methoxy-4-methyl-5-nitro pyridine 2-iodo-5-bromo pyridine 2-amino-4-methyl-5-nitro pyridine 5-Fluoro-2-Oxindole methyl L-alaninate hydrochloride diethyl L-glutamate hydrochloride Ethyl tosylcarbamateRelated products of tetrahydrofuran
![Choline chloride](https://img.chemicalbook.in/CAS/GIF/67-48-1.gif)
![Methyl](https://img.chemicalbook.in/CAS/GIF/57943-82-5.gif)
![Kresoxim-methyl](https://img.chemicalbook.in/CAS/GIF/143390-89-0.gif)
![Thiophanate-methyl](https://img.chemicalbook.in/CAS/GIF/23564-05-8.gif)
![Oxalyl chloride](https://img.chemicalbook.in/CAS/GIF/79-37-8.gif)
![Bensulfuron methyl](https://img.chemicalbook.in/CAS/GIF/83055-99-6.gif)
![Calcium chloride](https://img.chemicalbook.in/CAS/GIF/10043-52-4.gif)
![Methyl acrylate](https://img.chemicalbook.in/CAS/GIF/96-33-3.gif)
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