CH5138303
- CAS NO.：959763-06-5
- Empirical Formula: C19H18ClN5O2S
- Molecular Weight: 415.9
- MDL number: MFCD28099815
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:16
What is CH5138303?
Description
CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.
References
[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.
Properties of CH5138303
| Boiling point: | 813.1±75.0 °C(Predicted) |
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO |
| form | solid |
| pka | 16.39±0.40(Predicted) |
| color | White to off-white |
Safety information for CH5138303
Computed Descriptors for CH5138303
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