NVP-HSP990(HSP990)
- CAS NO.:934343-74-5
- Empirical Formula: C20H18FN5O2
- Molecular Weight: 379.39
- MDL number: MFCD22628859
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:03
What is NVP-HSP990(HSP990)?
The Uses of NVP-HSP990(HSP990)
NVP-HSP990 is an orally available HSP90 inhibitor.
What are the applications of Application
HSP-990 is an inhibitor of Hsp90
Biological Activity
hsp990 (nvp-hsp990) is a potent and selective inhibitor of hsp90 with ic50 values of 0.6, 0.8 and 8.5 nm for hsp90α, hsp90β and grp94, respectively [1].heat shock protein 90 (hsp90) is a chaperone protein that stabilizes proteins against heat stress, assists proteins to fold properly and aids in protein degradation. also, hsp90 stabilizes proteins required for tumor growth.hsp990 (nvp-hsp990) is a potent and selective hsp90 inhibitor. nvp-hsp990 bound to the n-terminal atp-binding domain of hsp90. nvp-hsp990 inhibited trap1 atpase activity by 90% with ic50 value of 320 nm. in gtl-16 cells, nvp-hsp990 destabilized the hsp90-p23 complex in a concentration- and time-dependent way. also, nvp-hsp990 decreased c-met with ec50 value of 37 nm and induced hsp70 with ec50 value of 20 nm. nvp-hsp990 inhibited erk and akt phosphorylation with ec50 values of 11 and 6 nm respectively and thus inhibited erk and akt activation. in five human tumor cell lines, nvp-hsp990 inhibited cell growth with gi50 values of 4-40 nm [1]. in glioma tumor-initiating cells, nvp-hsp990 inhibited cell growth with ic50 value of 10-500 nm in a dose-dependent way and reduced cdk2 and cdk4, thus disrupting cell-cycle control [2].in the gtl-16 gastric cancer mice model, nvp-hsp990 exhibited antitumor efficacy [1].
References
[1]. menezes dl, taverna p, jensen mr, et al. the novel oral hsp90 inhibitor nvp-hsp990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. mol cancer ther, 2012, 11(3): 730-739.
[2]. fu j, koul d, yao j, et al. novel hsp90 inhibitor nvp-hsp990 targets cell-cycle regulators to ablate olig2-positive glioma tumor-initiating cells. cancer res, 2013, 73(10): 3062-3074.
Properties of NVP-HSP990(HSP990)
Density | 1.332 |
storage temp. | Store at -20°C |
solubility | insoluble in H2O; insoluble in EtOH; ≥12.3 mg/mL in DMSO |
form | solid |
color | Off-white to yellow |
Safety information for NVP-HSP990(HSP990)
Computed Descriptors for NVP-HSP990(HSP990)
New Products
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