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HomeProduct name listCGP 52432

CGP 52432

Synonym(s):[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid

  • CAS NO.:139667-74-6
  • Empirical Formula: C15H24Cl2NO4P
  • Molecular Weight: 384.24
  • MDL number: MFCD09878290
  • EINECS: 000-000-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
CGP 52432 Structural

What is CGP 52432?

The Uses of CGP 52432

CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:

  • to study its effects on the simulation of the onset of status epilepticus (SE) in mice
  • for voltage-clamp recording in mice neurons
  • to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus

What are the applications of Application

CGP 52432 is A selective and effective GABAB receptor antagonist

Definition

ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.

Biological Activity

Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).

Biochem/physiol Actions

CGP52432 participates in inhibiting the glycine overflow in the hippocampus.

storage

+4°C (desiccate)

Properties of CGP 52432

Boiling point: 544.4±50.0 °C(Predicted)
Density  1.258±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: soluble1mg/mL, clear (warmed)
form  powder
pka 2.26±0.50(Predicted)
color  white to beige
Water Solubility  Soluble in water (10mM, gentle warming)

Safety information for CGP 52432

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for CGP 52432

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