CGP 52432
Synonym(s):[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid
- CAS NO.:139667-74-6
- Empirical Formula: C15H24Cl2NO4P
- Molecular Weight: 384.24
- MDL number: MFCD09878290
- EINECS: 000-000-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is CGP 52432?
The Uses of CGP 52432
CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:
- to study its effects on the simulation of the onset of status epilepticus (SE) in mice
- for voltage-clamp recording in mice neurons
- to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus
What are the applications of Application
CGP 52432 is A selective and effective GABAB receptor antagonist
Definition
ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene.
Biological Activity
Potent, selective GABA B receptor antagonist (IC 50 = 85 nM).
Biochem/physiol Actions
CGP52432 participates in inhibiting the glycine overflow in the hippocampus.
storage
+4°C (desiccate)
Properties of CGP 52432
Boiling point: | 544.4±50.0 °C(Predicted) |
Density | 1.258±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | H2O: soluble1mg/mL, clear (warmed) |
form | powder |
pka | 2.26±0.50(Predicted) |
color | white to beige |
Water Solubility | Soluble in water (10mM, gentle warming) |
Safety information for CGP 52432
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CGP 52432
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
TRIMETHYLSILYL ISOTHIOCYANATE
Methylene dithiocyanate
BENZYL ISOTHIOCYANATE
3-AMINOPROPYL(METHYL)PHOSPHINIC ACID HCL
CGP 52432
CGP 35348
Hypophosphorous acid
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