CGP 35348
Synonym(s):(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate
- CAS NO.:123690-79-9
- Empirical Formula: C8H20NO4P
- Molecular Weight: 225.22
- MDL number: MFCD00882736
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:50:00
What is CGP 35348?
The Uses of CGP 35348
CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
- to study its effects on intrinsic optical signal (IOS) in rat hippocampus
- alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
- to study its effects on hepatocellular carcinoma cells (HCC)
What are the applications of Application
CGP 35348 is a selective GABAB receptor antagonist
Biological Activity
Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
Biochem/physiol Actions
CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.
storage
Room temperature
References
[1]. olpe hr, karlsson g, pozza mf, et al. cgp 35348: a centrally active blocker of gabab receptors. eur j pharmacol, 1990, 187(1): 27-38.
[2]. hammond dl, washington jd. antagonism of l-baclofen-induced antinociception by cgp 35348 in the spinal cord of the rat. eur j pharmacol, 1993, 234(2-3): 255-262.
[3]. hao jx, xu xj, wiesenfeld-hallin z. intrathecal gamma-aminobutyric acidb (gabab) receptor antagonist cgp 35348 induces hypersensitivity to mechanical stimuli in the rat. neurosci lett, 1994, 182(2): 299-302.
[4]. patel sm, ebenezer is. the effects of intraperitoneal and intracerebroventricular administration of the gabab receptor antagonist cgp 35348 on food intake in rats. eur j pharmacol, 2004, 503(1-3): 89-93.
Properties of CGP 35348
storage temp. | −20°C |
solubility | H2O: >10 mg/mL |
form | solid |
color | white |
Water Solubility | Soluble in water (100mM) |
Safety information for CGP 35348
Computed Descriptors for CGP 35348
Related products of tetrahydrofuran
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