Cetrorelix acetate
- CAS NO.:130143-01-0
- Empirical Formula: C70H92N17O14
- Molecular Weight: 1551.16
- MDL number: MFCD00884467
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-27 11:49:37
What is Cetrorelix acetate?
Clinical Use
Cetrorelix acetate is an analogue of GnRH with amino acid substitutions at residues 1, 2, 3, 6, and 10 and differing from ganirelix at amino acids 1, 6, and 8. Each of these substitutions are synthetic, non-DNA-directed amino acids and, like ganirelix acetate, impart GnRH antagonist activity to cetrorelix acetate. This drug also is marketed for use in women undergoing assisted reproductive therapy (ART) procedures, in which it is necessary to control their LH surge. This allows the follicles to develop to a size, as determined by ultrasound, that increases the success of timed insemination and oocyte retrieval for IVF. Like ganirelix acetate, cetrorelix acetate has an advantage over GnRH agonists, such as leuprolide acetate, because it reduces the fertility therapy cycle to days rather than weeks.
Properties of Cetrorelix acetate
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO:50.0(Max Conc. mg/mL);33.53(Max Conc. mM) Water:2.0(Max Conc. mg/mL);1.34(Max Conc. mM) |
CAS DataBase Reference | 130143-01-0(CAS DataBase Reference) |
Safety information for Cetrorelix acetate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cetrorelix acetate
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