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HomeProduct name listCetrorelix acetate

Cetrorelix acetate

Cetrorelix acetate Structural

What is Cetrorelix acetate?

Clinical Use

Cetrorelix acetate is an analogue of GnRH with amino acid substitutions at residues 1, 2, 3, 6, and 10 and differing from ganirelix at amino acids 1, 6, and 8. Each of these substitutions are synthetic, non-DNA-directed amino acids and, like ganirelix acetate, impart GnRH antagonist activity to cetrorelix acetate. This drug also is marketed for use in women undergoing assisted reproductive therapy (ART) procedures, in which it is necessary to control their LH surge. This allows the follicles to develop to a size, as determined by ultrasound, that increases the success of timed insemination and oocyte retrieval for IVF. Like ganirelix acetate, cetrorelix acetate has an advantage over GnRH agonists, such as leuprolide acetate, because it reduces the fertility therapy cycle to days rather than weeks.

Properties of Cetrorelix acetate

storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  DMSO:50.0(Max Conc. mg/mL);33.53(Max Conc. mM)
Water:2.0(Max Conc. mg/mL);1.34(Max Conc. mM)
CAS DataBase Reference 130143-01-0(CAS DataBase Reference)

Safety information for Cetrorelix acetate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Cetrorelix acetate

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