CeftazidiMe
Synonym(s):1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum;Ceftazidime pentahydrate
- CAS NO.:72558-82-8
- Empirical Formula: C22H22N6O7S2
- Molecular Weight: 546.57
- MDL number: MFCD00072034
- EINECS: 276-715-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is CeftazidiMe?
Absorption
Ceftazidime administered intravenously in healthy males produced mean Cmax values of between 42 and 170 μg/mL for doses between 500 mg and 2 g, and are reached immediately following the end of the infusion period. The Cmax for 1 g of ceftazidime administered intramuscularly is attained approximately one hour following injection and is between 37 and 43 mg/L. Following intramuscular administration of 500 mg and 1 g of ceftazidime, the serum concentration remained above 4 μg/mL for six and eight hours, respectively.
Ceftazidime Cmax and AUC show linear proportionality to the dose over the therapeutic range. In individuals with normal renal function, ceftazidime given intravenously every eight hours for 10 days as either 1 or 2 g doses showed no accumulation.
Toxicity
Ceftazidime overdosage has occurred in patients with renal failure. Reactions included seizure activity, encephalopathy, asterixis, neuromuscular excitability, and coma. Patients who receive an acute overdosage should be carefully observed and given supportive treatment. In the presence of renal insufficiency, hemodialysis or peritoneal dialysis may aid in the removal of ceftazidime from the body.
Description
In ceftazidime the oxime moiety is more complex, containing two methyl groups and a carboxylic acid. This assemblage conveys even more pronounced β-lactamase stability, greater anti–Pseudomonas aerugi nosa, and increased activity against Gram-positive organisms. The C-3 side chain has been replaced by a charged pyridinium moiety. The latter considerably enhances water solubility and also highly activates the β-lactam bond toward cleavage. The drug must be protected against heat and light and may darken without significant loss of potency. It is not stable under some conditions. such as the presence of aminoglycosides and vancomycin. It also is attacked readily in sodium bicarbonate solutions. Resistance is mediated by chromosomally mediated β-lactamases and by lack of penetration into target bacteria. Otherwise, it has a very broad antibacterial spectrum.
Chemical properties
solid
Originator
Fortum,Glaxo,UK,1983
The Uses of CeftazidiMe
Like most of the third-generation cephalosporin antibiotics described above, ceftazidime has a broad spectrum of antimicrobial action, including the most clinically important microorganisms: Gram-positive, Gram-negative, aerobic, and anaerobic. It is resistant to most beta-lactamases of Gram-positive and Gram-negative bacteria. It is used for treating most serious bacterial infections. Synonyms of this drug are fortum, ceftim, stacef, and tazicef.
The Uses of CeftazidiMe
Third generation cephalosporin antibiotic. Antibacterial
The Uses of CeftazidiMe
5-HT agonist, anti-migrane
The Uses of CeftazidiMe
pyrimidine synthesis inhibitor disease-modifying antirheumatic drug
Indications
Ceftazidime is indicated for the treatment of lower respiratory tract infections, skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra-abdominal infections (including peritonitis), and central nervous system infections (including meningitis) caused by susceptible bacteria.
Ceftazidime is indicated in combination with avibactam to treat infections caused by susceptible Gram-negative organisms, including complicated intra-abdominal infections (cIAI), in conjunction with metronidazole, and complicated urinary tract infections (cUTI), including pyelonephritis, in patients aged three months and older. This combination is also indicated to treat hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) in patients aged 18 years and older.
In all cases, to mitigate the risk of bacterial resistance and preserve clinical efficacy, ceftazidime should only be used for infections that are confirmed or strongly suspected to be caused by susceptible bacterial strains.
Background
Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of essential PBPs, result in impaired cell wall homeostasis, loss of cell integrity, and ultimately bacterial cell death. Ceftazidime is a third-generation cephalosporin with broad-spectrum antibacterial activity, including against some treatment-resistant bacteria such as Pseudomonas aeruginosa.
Ceftazidime was approved by the FDA on July 19, 1985, and is currently available either alone or in combination with the non-β-lactam β-lactamase inhibitor avibactam to treat a variety of bacterial infections.
What are the applications of Application
Ceftazidime is an antimicrobial small molecule
Definition
ChEBI: A cephalosporin bearing pyridinium-1-ylmethyl and {[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
Manufacturing Process
(a) t-Butyl(6R,7R)-3-acetoxymethyl-7-[(Z)-2-(2-t-butoxycarbonylprop-2-
oxyimino)-2-(2-tritylaminothiazol-4-yl)acetamido]ceph-3-em-4-carboxylate: A
stirred solution of (Z)-2-(2-t-butoxycarbonylprop-2-oxyimino)-2-(2-
tritylaminothiazol-4-yl)acetic acid (572 mg) and t-butyl(6R,7R)-3-
acetoxymethyl-7-aminoceph-3-em-4-carboxylate (328 mg) in
dimethylformamide (10 ml) was cooled to 0°C, and 1-hydroxybenzotriazole
(150 mg) was added, followed by dicyclohexylcarbodiimide (225 mg). The
mixture was warmed to room temperature, stirred for 5 hours and allowed to
stand overnight. The mixture was filtered, and the white solid washed with a
little ether. The filtrate and washings were diluted with water (50 ml) and
extracted with ethyl acetate. The organic extracts were combined, washed
successively with water, 2 N hydrochloric acid, water, sodium bicarbonate
solution, and saturated brine, dried and evaporated. The residue was eluted
through a silica column with ether. The product-containing eluate was
collected and concentrated to give the title compound (533 mg). A portion
was recrystallized from diisopropyl ether, MP 103°C to 113°C (decomp.);
[α]D20 +8.5 (conc. 1.0, DMSO).
(b) (6R,7R)-3-Acetoxymethyl-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-
carboxyprop-2-oxyimino)acetamido]ceph-3-em-4-carboxylic acid:
Trifluoroacetic acid (18 ml) was added to a solution of the product of (a) (2.4
g) in anisole (18 ml) at 0°C. The mixture was stirred at room temperature for
2 hours and concentrated. The residue was dissolved in ethyl acetate and
extracted with saturated sodium bicarbonate solution. The pH of the aqueous
extracts was adjusted to 6, and the solution washed with ethyl acetate. The
aqueous phase was acidified to pH 1.5 under ethyl acetate, saturated with
sodium chloride, and extracted with ethyl acetate. The combined organic
extracts were washed with saturated brine, dried and evaporated. The residue
was dissolved in warm 50% aqueous formic acid (20 ml) and allowed to stand
for 2 hours. The mixture was diluted with water (50 ml) and filtered. The
filtrate was concentrated. The residue was taken up in water (50 ml),
refiltered, and lyophilized to give the title compound (920 mg).
(c) (6R,7R)-7-[(Z)-(2-Aminothiazol-4-yl)-2-(2-carboxyprop-2-
oxyimino)acetamido]-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylate,
monosodium salt: Pyridine (2 ml) and the product of (b) (1.8 g) were added
to a stirred solution of sodium iodide (7.12 g) in water (2.2 ml) at 80°C. The
solution was stirred at 80 C for 1 hour, cooled, and diluted to 100 ml with
water. The pH of the solution was adjusted to 6.0 with 2N sodium hydroxide
solution, and this solution was concentrated to remove pyridine. The aqueous
residue was diluted to 100 ml with water, methyl isobutyl ketone (2 drops) was added, and the solution was acidified to pH 1 with 2 N hydrochloric acid.
The mixture was filtered, and the solid was washed with a little water. The
filtrate and washings were collected and washed with ethyl acetate, and the
pH adjusted to 6.0 with 2 N sodium hydroxide solution. The solution was
concentrated to 50 ml and applied to a column of 500 g Amberlite XAD-2
resin, using first water and then 20% aqueous ethanol as eluting solvent. The
product-containing fractions were concentrated and lyophilized to give the title
compound (0.56 g).
brand name
Fortaz (GlaxoSmithKline); Tazicef (Hospira); Tazidime (Lilly).
Therapeutic Function
Antibiotic
Pharmacokinetics
Ceftazidime is a semisynthetic, broad-spectrum, third-generation cephalosporin antibiotic that is bactericidal through inhibition of enzymes responsible for cell-wall synthesis, primarily penicillin-binding protein 3 (PBP3). Among cephalosporins, ceftazidime is notable for its resistance to numerous β-lactamases and its broad spectrum of activity against Gram-negative bacteria, including Pseudomonas aeruginosa. However, it is less active than first- and second-generation cephalosporins against Staphylococcus aureus and other Gram-positive bacteria and also has low activity against anaerobes. Ceftazidime has confirmed activity against clinically relevant Gram-negative bacteria including Citrobacter spp., Enterobacter spp., Klebsiella spp., Proteus spp., Serratia spp., _Escherichia coli, Haemophilus influenzae, Neisseria meningitidis, Pseudomonas aeruginosa, and some Gram-positive bacteria including Staphylococcus spp. and Streptococcus spp. There are also in vitro data for ceftazidime efficacy against a wide variety of other bacteria, such as Acinetobacter baumannii and Neisseria gonorrhoeae, but no clear clinical studies to support the use of ceftazidime for infections caused by these bacteria.
Although β-lactam antibiotics like ceftazidime are generally well tolerated, there remains a risk of serious acute hypersensitivity reactions, which is higher in patients with a known allergy to ceftazidime or any other β-lactam antibiotic. As with all antibiotics, ceftazidime may result in the overgrowth of non-susceptible organisms and potentially serious effects including Clostridium difficile-associated diarrhea (CDAD); CDAD should be considered in patients who develop diarrhea and, in confirmed cases, supportive care initiated immediately. Ceftazidime is primarily renally excreted such that high and prolonged serum concentrations can occur in patients with renal insufficiency, leading to seizures, nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia. Treatment may lead to the development or induction of resistance with a risk of treatment failure. Periodic susceptibility testing should be considered, and monotherapy failure may necessitate the addition of another antibiotic such as an aminoglycoside. Cephalosporin use may decrease prothrombin activity, which may be improved by exogenous vitamin K. Inadvertent intra-arterial administration of ceftazidime may result in distal necrosis.
Clinical Use
Antibacterial agent
Synthesis
Ceftazidime is 1-[[7-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)
imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-
yl]methyl]pyridin-2-carboxylic acid (32.1.2.82). As is the case in synthesis of ceftriazone,
the synthesis of ceftazidime requires the preliminary synthesis of two starting compounds. 7-Amino-3-(1-pyridinomethyl)cef-3-en-carboxylic acid dihydrochloride is used as the cephalosporin fragment, while the acyl fragment is a modified structure of
(32.1.2.77), which is not a derivative of 2-(2-amino-4-thiazolyl)-2-methoxyminoacetic
acid, but a derivative of 2-(2-amino-4-thiazolyl)-2-(2-tert-butoxycarboxyl-2-propyloximino)acetic acid, which is synthesized by the following scheme. Nitration of acetoacetic ester gives isonitrosoacetoacetic ester (32.1.2.49), which undergoes chlorination
by sulfuryl chloride in methylene chloride to form 4-chloro-2-hydroximinoacetoacetic
ester (32.1.2.73).
Reacting this with thiourea in the classic scheme of thiazole synthesis by reacting of
|á-halogencarbonyl compounds with thioamides forms the ethyl ester of (Z)-2-(2-aminothiazole-4-yl)-2-hydroxyminoacetic acid (32.1.2.74). The amino group in this molecule is
protected by a reaction with triphenylchloromethane in dimethylformamide in the presence of triethylamine, which gives the ethyl ester of (Z)-2-(2-tritylaminothiazole-4-yl)-
2-hydroxyminoacetic acid (32.2.3.75). The hydroxyl group in the resulting compound is
alkylated with the tert-butyl ester of |á-bromoisobutyric acid in dimethylsulfoxide in the
presence of potassium carbonate, giving ethyl ester of 4-thiazoleacetic acid,
|á -[[2-(1,1-dimethylethoxy)-1,1-dimethyl-2-oxoethoxy]imino]-2-
[(triphenylmethyl)amino], (Z) (32.1.2.76). The ethoxycarbonyl group in this molecule is
hydrolyzed by sodium hydroxide, and upon working up the reaction mixture with an acid,
the corresponding acid (32.1.2.77) is isolated (32.1.2.77). Upon interaction with phosphorous pentachloride the acid chloride (32.1.2.78) is obtained, which is used further as the
acylating reagent.
The second necessary fragment, 7-amino-3-(1-pyridinomethyl)cef-3-en-carbonic acid
(32.1.2.80), is synthesized from cefalosporidin (32.1.2.79), a cephalosporin antibiotic that
is used independently in medicine and which is synthesized in the form of an internal salt
by reacting cefalotin (32.1.2.1) with pyridine to replace the acetoxyl group with a pyridine
group. Initially treating cephaloridin with trimethylchlorosilane in the presence of
dimethylaniline and then with phosphorous pentachloride, followed by a reaction with 1,
3-butandiol results in the creation of 7-amino-3-(1-pyridinomethyl)cef-3-en-carboxylic
acid (32.1.2.80). This is acylated by the acid chloride (32.1.2.78) synthesized earlier, forming the product (32.1.2.81), which is treated with a mixture of formic and hydrochloric
acids to remove both protective groups (triphenylmethyl and tert-butyl), giving ceftazidime (32.1.2.82) in the form of a dihydrochloride.
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effects of coumarins may be
enhanced.
Ciclosporin: may cause increased ciclosporin levels.
Metabolism
Ceftazidime is not appreciably metabolized.
Metabolism
Ceftazidime is passively excreted in bile, although only a small proportion (1%) is eliminated by this route. It is mainly excreted by the kidneys, almost exclusively by glomerular filtration; probenecid has little effect on the excretion. About 80-90% of a dose appears unchanged in the urine within 24 hours.
Properties of CeftazidiMe
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | ≥21.25 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
form | powder to crystal |
color | White to Orange to Green |
Merck | 14,1946 |
Stability: | Stable, but keep refrigerated. Incompatible with strong oxidizing agents, nitric acid, permanganates, peroxides. |
Safety information for CeftazidiMe
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P501:Dispose of contents/container to..… |
Computed Descriptors for CeftazidiMe
Abamectin manufacturer
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