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HomeProduct name listCC0651

CC0651

Synonym(s):;Cdc34 Inhibitor, CC0651 - CAS 1319207-44-7 - Calbiochem

CC0651 Structural

What is CC0651?

General Description

A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

Properties of CC0651

Boiling point: 755.7±60.0 °C(Predicted)
Density  1.410±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO: ≥ 56 mg/mL (126.61 mM)
form  Powder
pka 3.37±0.34(Predicted)
color  White to off-white

Safety information for CC0651

Computed Descriptors for CC0651

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