AGI6780

Synonym(s):IDH2 Inhibitor, R140Q Somatic Mutant-Specific, AGI-6780 - CAS 1432660-47-3 - Calbiochem;Isocitrate Dehydrogenase 2 R140 Somatic Mutant Inhibitor, AGI6780;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide

CAS NO.：1432660-47-3
Empirical Formula: C21H18F3N3O3S2
Molecular Weight: 481.51
MDL number: MFCD26097285
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-08 20:21:46

What is AGI6780?

The Uses of AGI6780

AGI-6780 is a small molecule inhibitor of the tumor associated mutant IDH2 (Isocitrate Dehydrogenase-2) in leukemia cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research.

Biological Activity

agi-6780 is a potent and selective inhibitor of tumor-associated idh2/r140q mutation with ic50 value of 23 nm [1].agi-6780 could significantly reduce intracellular concentration of 2hg in the human glioblastoma tf1/r140q cells, as well as reverse idh2/r140q-mediated differentiation block in tf1 cells in the presence of epo. agi-6780 could restore klf1 and hemoglobin g1/2 expressions in the epo-induced tf1/r140q cells [1].

References

[1] wang f1, travins j, delabarre b, penard-lacronique v, schalm s, hansen e, straley k, kernytsky a, liu w, gliser c, yang h, gross s, artin e, saada v,mylonas e, quivoron c, popovici-muller j, saunders jo, salituro fg, yan s, murray s, wei w, gao y, dang l, dorsch m, agresta s, schenkein dp, biller sa, su sm, de botton s, yen ke. targeted inhibition of mutant idh2 in leukemia cells induces cellular differentiation. science. 2013 may 3;340(6132):622-6.

Properties of AGI6780

Density	1.52±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥22.25 mg/mL in DMSO; insoluble in H2O; ≥100.8 mg/mL in EtOH
form	solid
pka	11.78±0.20(Predicted)
color	White to off-white