AGI6780
Synonym(s):IDH2 Inhibitor, R140Q Somatic Mutant-Specific, AGI-6780 - CAS 1432660-47-3 - Calbiochem;Isocitrate Dehydrogenase 2 R140 Somatic Mutant Inhibitor, AGI6780;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide
- CAS NO.：1432660-47-3
- Empirical Formula: C21H18F3N3O3S2
- Molecular Weight: 481.51
- MDL number: MFCD26097285
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is AGI6780?
The Uses of AGI6780
AGI-6780 is a small molecule inhibitor of the tumor associated mutant IDH2 (Isocitrate Dehydrogenase-2) in leukemia cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research.
Biological Activity
agi-6780 is a potent and selective inhibitor of tumor-associated idh2/r140q mutation with ic50 value of 23 nm [1].agi-6780 could significantly reduce intracellular concentration of 2hg in the human glioblastoma tf1/r140q cells, as well as reverse idh2/r140q-mediated differentiation block in tf1 cells in the presence of epo. agi-6780 could restore klf1 and hemoglobin g1/2 expressions in the epo-induced tf1/r140q cells [1].
References
[1] wang f1, travins j, delabarre b, penard-lacronique v, schalm s, hansen e, straley k, kernytsky a, liu w, gliser c, yang h, gross s, artin e, saada v,mylonas e, quivoron c, popovici-muller j, saunders jo, salituro fg, yan s, murray s, wei w, gao y, dang l, dorsch m, agresta s, schenkein dp, biller sa, su sm, de botton s, yen ke. targeted inhibition of mutant idh2 in leukemia cells induces cellular differentiation. science. 2013 may 3;340(6132):622-6.
Properties of AGI6780
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥22.25 mg/mL in DMSO; insoluble in H2O; ≥100.8 mg/mL in EtOH |
| form | solid |
| pka | 11.78±0.20(Predicted) |
| color | White to off-white |
Safety information for AGI6780
Computed Descriptors for AGI6780
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1,1’-CARBONYLDIIMIDAZOLE DIETHYL AMINOMALONATE HYDROCHLORIDE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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