Palmatine chloride
- CAS NO.:10605-02-4
- Empirical Formula: C21H22ClNO4
- Molecular Weight: 387.86
- MDL number: MFCD00016656
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-04 21:29:30
What is Palmatine chloride?
Description
Corydalis paUida yields this alkaloid which occurs in the quaternary base fraction. The alkaloid is separated by droplet countercurrent chromatography and crystallizes from H20 as yellow-green needles.
Description
Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 μM, respectively). Palmatine (20, 40, and 80 μM) reduces Zika virus infection of Vero cells in a concentration-dependent manner. In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; ). It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers. Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.
The Uses of Palmatine chloride
Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent.
The Uses of Palmatine chloride
antibacterial, antimalarial, uterine contractant
What are the applications of Application
Palmatine chloride is a protoberberine alkaloid and an inhibitor of dopamine generation which reduces Ca2+ levels
References
Tani, Nakagura, Hattori, Yakugaku Zasshi, 95, 1103 (1975)
Properties of Palmatine chloride
Melting point: | 205℃ |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
solubility | Chloroform (Slightly), DMSO (Slightly) |
form | Solid |
color | Yellow |
InChI | InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1 |
Safety information for Palmatine chloride
Computed Descriptors for Palmatine chloride
InChIKey | RLQYRXCUPVKSAW-UHFFFAOYSA-M |
SMILES | C12=CC3=C(C(OC)=C(OC)C=C3)C=[N+]1CCC1C=C(OC)C(OC)=CC2=1.[Cl-] |
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