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HomeProduct name listPalmatine chloride

Palmatine chloride

Palmatine chloride Structural

What is Palmatine chloride?

Description

Corydalis paUida yields this alkaloid which occurs in the quaternary base fraction. The alkaloid is separated by droplet countercurrent chromatography and crystallizes from H20 as yellow-green needles.

Description

Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 μM, respectively). Palmatine (20, 40, and 80 μM) reduces Zika virus infection of Vero cells in a concentration-dependent manner. In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; ). It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers. Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.

The Uses of Palmatine chloride

Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent.

The Uses of Palmatine chloride

antibacterial, antimalarial, uterine contractant

What are the applications of Application

Palmatine chloride is a protoberberine alkaloid and an inhibitor of dopamine generation which reduces Ca2+ levels

References

Tani, Nakagura, Hattori, Yakugaku Zasshi, 95, 1103 (1975)

Properties of Palmatine chloride

Melting point: 205℃
storage temp.  Hygroscopic, Refrigerator, under inert atmosphere
solubility  Chloroform (Slightly), DMSO (Slightly)
form  Solid
color  Yellow
InChI InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1

Safety information for Palmatine chloride

Computed Descriptors for Palmatine chloride

InChIKey RLQYRXCUPVKSAW-UHFFFAOYSA-M
SMILES C12=CC3=C(C(OC)=C(OC)C=C3)C=[N+]1CCC1C=C(OC)C(OC)=CC2=1.[Cl-]

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