Carprofen
Synonym(s):6-Chloro-α-methyl-9H-carbazole-2-acetic acid;CAR;Carprofen
- CAS NO.:53716-49-7
- Empirical Formula: C15H12ClNO2
- Molecular Weight: 273.71
- MDL number: MFCD00079028
- EINECS: 258-712-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-31 17:33:32
What is Carprofen?
Absorption
Rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally.
Toxicity
Symptoms of NSAID overdose include dizziness and nystagmus. Oral LD50 in mouse and rat is 282 mg/kg and 149 mg/kg, respectively.
Description
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in animals to combat pain and inflammation, particularly as associated with osteoarthritis. Like many NSAIDs, carprofen inhibits both cyclooxygenases COX-1 and COX-2 (IC50s = 22.3 and 3.9 μM, respectively). It also inhibits fatty acid amide hydrolase (IC50 = 74 μM), blocking the metabolism of the cannabinoid receptor ligand, arachidonoyl ethanolamide .
The Uses of Carprofen
Carprofen is a non steroidal anti-inflammatory that is used by veterinarians for the relief of arthritic systems in dogs. It can be used for joint pain or post operative inflammation. Carprofen, is al so used for the relief from pain and inflammation associated with osteoarthritis, hip dysplasia and other joint issues.
Indications
For use as a pain reliever in the treatment of joint pain and post-surgical pain.
Background
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal pain and nausea, similar to those recorded with aspirin and other non-steroidal anti-inflammatory drugs. It is no longer marketed for human usage, after being withdrawn on commercial grounds.
What are the applications of Application
Carprofen is an antiinflammatory inhibitor of COX-2
Pharmacokinetics
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. It is no longer used in the clinical setting, but is approved for use in dogs. Carprofen is non-narcotic and has characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.
Metabolism
Hepatic.
Properties of Carprofen
Melting point: | 186-1880C |
Boiling point: | 509.1±35.0 °C(Predicted) |
Density | 1.2011 (rough estimate) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO: soluble20mg/mL, clear |
form | powder |
color | white to beige |
Safety information for Carprofen
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Computed Descriptors for Carprofen
InChIKey | PUXBGTOOZJQSKH-UHFFFAOYSA-N |
SMILES | N1C2=C(C=C(Cl)C=C2)C2=C1C=C(C(C)C(O)=O)C=C2 |
Abamectin manufacturer
NGL Fine Chem limited
Zenfold Sustainable Technologies (ZST)
Adani Wilmar Limited
Alivira Animal Health Ltd
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