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HomeProduct name listCarbonic Anhydrase IX/XII Inhibitor II(U-104)

Carbonic Anhydrase IX/XII Inhibitor II(U-104)

Synonym(s):4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide;NSC 213841

Carbonic Anhydrase IX/XII Inhibitor II(U-104) Structural

What is Carbonic Anhydrase IX/XII Inhibitor II(U-104)?

The Uses of Carbonic Anhydrase IX/XII Inhibitor II(U-104)

U 104 targets hypoxia-induced carbonic anhydrase IX, which inhibits tumor growth and metastasis.

Biological Activity

u-104 is a novel ureido-sulfonamide inhibitor of carbonic anhydrase ix (caix). tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the u-104 compound compared with vehicle controls. it also has ability to inhibit metastasis formation in the 4t1 experimental metastasis model.yuanmei lou, paul c. mcdonald, arusha oloumi, stephen chia, christina ostlund, ardalan ahmadi, alastair kyle, ulrich auf dem keller, samuel leung, david huntsman, blaise clarke, brent w. sutherland, dawn waterhouse, marcel bally, calvin roskelley, christopher m. overall, andrew minchinton, fabio pacchiano, fabrizio carta, andrea scozzafava, nadia touisni, jean-yves winum, claudiu t. supuran, shoukat dedhar. targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase ix inhibitors. cancer research may 1, 2011 71; 3364

Biochem/physiol Actions

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

Properties of Carbonic Anhydrase IX/XII Inhibitor II(U-104)

Melting point: 242-243℃
Density  1.523±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.  2-8°C
solubility  DMSO: >15mg/mL
form  powder
pka 9.94±0.12(Predicted)
color  white to beige

Safety information for Carbonic Anhydrase IX/XII Inhibitor II(U-104)

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H320:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Carbonic Anhydrase IX/XII Inhibitor II(U-104)

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