Carbadox
Synonym(s):3-(2-Quinoxalinylmethylene)carbazic acid methyl ester N,N′-dioxide
- CAS NO.:6804-07-5
- Empirical Formula: C11H10N4O4
- Molecular Weight: 262.22
- MDL number: MFCD00057293
- EINECS: 229-879-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-14 13:33:12
What is Carbadox?
Chemical properties
Yellow Crystalline Solid
Originator
Carbadox,Agrimex
The Uses of Carbadox
Carbadox has been used to suppress aldosterone production, to study the spread of shiga toxin-producing Escherichia coli (STEC) strains, and to compare different antimicrobial activities. Carbadox is a quinoxaline-di-N-oxide antibiotic that is generally used in feed to swine to prevent dysentery and improve feed efficiency. It inhibits bacteria by intercalation and induction of mutations in bacterial genome.
What are the applications of Application
Carbadox is a broad spectrum antimicrobial agent
Definition
ChEBI: Carbadox is a quinoxaline derivative.
Manufacturing Process
A solution of methylcarbazate (48.0 mg) in methanol (250 ml) is added all at
once at room temperature to a well stirred solution of 2-formylquinoxaline-
1,4-dioxide (100 g) in methanol (2.5 liters). Two drops of concentrated
hydrochloric acid are added. The mixture is stirred for 3 hours then filtered to remove the yellow crystalline product. The crystals of (2-
quinoxalinylmethylene)hydrazinecarboxylic acid methyl ester are washed with
methanol then air dried; M.P. 234.5-236°C (dec.). Yield=121.8 g. The product
is purified by refluxing in chloroform for 2 hours, followed by filtration and air
drying; M.P. 239.5-240°C (dec.).
The ultraviolet absorption spectrum (water) exhibits maxima at 236, 251,
303, 366 and 373 nm with extinction coefficients of 11,000, 10,900, 36,400,
16,100 and 16,200, respectively.
brand name
Mecadox (Pfizer).
Therapeutic Function
Antibacterial
Biochem/physiol Actions
Carbadox is a quinoxaline-di-N-oxide antibiotic that is generally used in feed to swine to prevent dysentery and improve feed efficiency. It inhibits bacteria by intercalation and induction of mutations in bacterial genome.
Safety Profile
Moderately toxic by ingestion. Questionable carcinogen with experimental carcinogenic effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of Nox.
Properties of Carbadox
Melting point: | 239-240°C |
Boiling point: | 405.47°C (rough estimate) |
Density | 1.3602 (rough estimate) |
refractive index | 1.6000 (estimate) |
Flash point: | 18°(64°F) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly, Sonicated) |
form | powder |
pka | 10.51±0.46(Predicted) |
color | Yellow to Dark Yellow |
Water Solubility | Soluble in 1N NaOH (50 mg/ml), and water (partly). |
Stability: | Light Sensitive |
CAS DataBase Reference | 6804-07-5 |
EPA Substance Registry System | Hydrazinecarboxylic acid, 2-[(1,4-dioxido-2-quinoxalinyl)methylene]-, methyl ester (6804-07-5) |
Safety information for Carbadox
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H228:Flammable solids H302:Acute toxicity,oral H350:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. |
Computed Descriptors for Carbadox
New Products
Tubulysin F Tubulysin M (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin G 2,2-diethoxyethanethioamide 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropylamine hydrochloride 3-Aminocyclobutanone hydrochloride tetrahydro-4-methyl-2H-pyran 3-N-BOC-(S)-AMINO BUTYRONITRILE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Hydrogen Gas 98%View Details
-
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8