CADP-RIBOSE
Synonym(s):ADP-cyclo[N1:1′′]-ribose;cADPR;cADP-ribose;Cyclic ADPR
- CAS NO.：119340-53-3
- Empirical Formula: C15H21N5O13P2
- Molecular Weight: 541.3
- MDL number: MFCD00214262
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is CADP-RIBOSE?
The Uses of CADP-RIBOSE
Cyclic adenosine diphosphate-ribose (cADPR) is an intracellular second messenger that mobilizes intracellular Ca2+ release from the sarcoplasmic reticulum through ryanodine receptors. CADPR is also a second messenger for glucose-induced insulin release from endocrine pancreas and for abscisic acid-induced calcium release in plants.
What are the applications of Application
cADP-Ribose (cADPR) is a potent second messenger for Ca22+ and a signaling molecule in abscisic acid response in plants
Definition
ChEBI: A cyclic purine nucleotide that is synthesised from NAD+ by ADP-ribosyl cyclase; acts as an agonist at ryanodine receptors.
Biochem/physiol Actions
Mobilizes intracellular Ca2+; regulates Ca2+-induced Ca2+?release specifically blocked by ryanodine; second messenger for glucose-induced insulin release from the endocrine pancreas and for abscisic acid-induced calcium release in plants.
Properties of CADP-RIBOSE
| Boiling point: | 934.8±75.0 °C(Predicted) |
| Density | 2.57±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly), Water (Slightly) |
| form | lyophilized powder |
| pka | 0.97±0.70(Predicted) |
| color | White to off-white |
| Stability: | Hygroscopic |
Safety information for CADP-RIBOSE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for CADP-RIBOSE
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