Bucumolol

Originator

Bucumarol,Sankyo,Japan,1982

The Uses of Bucumolol

Bucumolol is?an antihypertensive agent and a β-adrenoceptor blocker.

Definition

ChEBI: Bucumolol is a member of coumarins.

Manufacturing Process

A mixture of 3 g of 8-(2-hydroxy-3-chloropropoxy)-5-methyl coumarin, 4.3 g of t-butylamine and 60 ml of ethanol is heated at 100°C in a sealed tube for 15 hours. The reaction mixture is concentrated under reduced pressure to dryness. The residue is recrystallized from a mixture of ethanol and ether to give 2.1 g of the desired product melting at 226° to 228°C (with decomposition).
In practice it is usually used as hydrochloride.

Therapeutic Function

Beta-adrenergic blocker