Bucumolol
- CAS NO.：58409-59-9
- Empirical Formula: C17H23NO4
- Molecular Weight: 305.37
- MDL number: MFCD00864572
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Bucumolol?
Originator
Bucumarol,Sankyo,Japan,1982
The Uses of Bucumolol
Bucumolol is?an antihypertensive agent and a β-adrenoceptor blocker.
Definition
ChEBI: Bucumolol is a member of coumarins.
Manufacturing Process
A mixture of 3 g of 8-(2-hydroxy-3-chloropropoxy)-5-methyl coumarin, 4.3 g
of t-butylamine and 60 ml of ethanol is heated at 100°C in a sealed tube for
15 hours. The reaction mixture is concentrated under reduced pressure to
dryness. The residue is recrystallized from a mixture of ethanol and ether to
give 2.1 g of the desired product melting at 226° to 228°C (with
decomposition).
In practice it is usually used as hydrochloride.
Therapeutic Function
Beta-adrenergic blocker
Properties of Bucumolol
| Melting point: | >163° (dec.) |
| Boiling point: | 490.7±45.0 °C(Predicted) |
| Density | 1.160±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.81±0.20(Predicted) |
| color | White to Off-White |
Safety information for Bucumolol
Computed Descriptors for Bucumolol
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