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HomeProduct name listBromo-PEG4-t-butyl ester

Bromo-PEG4-t-butyl ester

Bromo-PEG4-t-butyl ester Structural

What is Bromo-PEG4-t-butyl ester?

Description

Bromo-PEG4-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Biological Activity

Br-PEG4-C2-Boc is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).

Properties of Bromo-PEG4-t-butyl ester

Boiling point: 415.8±35.0 °C(Predicted)
Density  1.210±0.06 g/cm3(Predicted)
solubility  Soluble in DMSO, DCM, DMF
form  Liquid
color  Colorless to light yellow

Safety information for Bromo-PEG4-t-butyl ester

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Bromo-PEG4-t-butyl ester

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