Bromo-PEG4-t-butyl ester
- CAS NO.：564476-32-0
- Empirical Formula: C15H29BrO6
- Molecular Weight: 385.29
- MDL number: MFCD22574808
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Bromo-PEG4-t-butyl ester?
Description
Bromo-PEG4-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Biological Activity
Br-PEG4-C2-Boc is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).
Properties of Bromo-PEG4-t-butyl ester
| Boiling point: | 415.8±35.0 °C(Predicted) |
| Density | 1.210±0.06 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| form | Liquid |
| color | Colorless to light yellow |
Safety information for Bromo-PEG4-t-butyl ester
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Bromo-PEG4-t-butyl ester
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