Bromo-PEG2-acid
- CAS NO.：1807503-92-9
- Empirical Formula: C7H13BrO4
- Molecular Weight: 241.08
- MDL number: MFCD28122969
- Update Date: 2024-07-02 08:55:00
What is Bromo-PEG2-acid?
Description
Bromo-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
The Uses of Bromo-PEG2-acid
Bromo-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of Bromo-PEG2-acid
| Boiling point: | 347.2±27.0 °C(Predicted) |
| Density | 1.464±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| pka | 4.27±0.10(Predicted) |
| form | Liquid |
| color | Light brown to yellow |
Safety information for Bromo-PEG2-acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Bromo-PEG2-acid
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