Bromo-PEG2-acid

CAS NO.：1807503-92-9
Empirical Formula: C7H13BrO4
Molecular Weight: 241.08
MDL number: MFCD28122969
Update Date: 2025-10-28 16:00:23

What is Bromo-PEG2-acid?

Description

Bromo-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

The Uses of Bromo-PEG2-acid

Bromo-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Properties of Bromo-PEG2-acid

Boiling point:	347.2±27.0 °C(Predicted)
Density	1.464±0.06 g/cm3(Predicted)
storage temp.	-20°C
pka	4.27±0.10(Predicted)
form	Liquid
color	Light brown to yellow

Safety information for Bromo-PEG2-acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.