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HomeProduct name listBrodimoprim

Brodimoprim

  • CAS NO.:56518-41-3
  • Empirical Formula: C13H15BrN4O2
  • Molecular Weight: 339.1878
  • MDL number: MFCD00864849
  • EINECS: 2602388
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-18 11:31:15
Brodimoprim Structural

What is Brodimoprim?

Description

Brodimoprim, a dihydrofolate reductase inhibitor, was introduced for the treatment of common infections of upper respiratory tract such as sinusitis and exacerbation of chronic bronchitis. It has a broad spectrum of antimicrobial activities against most Gram-positive and -negative pathogens including some bacterial strains that are resistant to amoxicillin, a widely used antibiotic for the indicated infections. Brodimoprim also has a favorable pharmacokinetic profile exemplified by its long half-life and good tissue penetration.

Chemical properties

Off-White to Pale Yellow Solid

Originator

Helsinn (Switzerland)

The Uses of Brodimoprim

A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.

Definition

ChEBI: An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group.

brand name

Hyprim;Unitrim

Properties of Brodimoprim

Melting point: 225-228°
storage temp.  Amber Vial, -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Methanol (Sparingly)
form  Solid
pka 7.15(at 25℃)
color  White to Pale Yellow
Stability: Light Sensitive

Safety information for Brodimoprim

Computed Descriptors for Brodimoprim

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