Boc-5-aminopentanoic acid
Synonym(s):5-(Boc-amino)pentanoic acid;5-(Boc-amino)valeric acid
- CAS NO.：27219-07-4
- Empirical Formula: C10H19NO4
- Molecular Weight: 217.26
- MDL number: MFCD00076903
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:43:00
What is Boc-5-aminopentanoic acid?
Description
Boc-5-aminopentanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. Boc-5-aminopentanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical properties
solid
The Uses of Boc-5-aminopentanoic acid
Boc-5-aminovaleric acid can be used to synthesize inhibitors of bacterial quorum seining and biofilm formation. It can also be used to synthesize diblock and triblock copolymers.
Synthesis Reference(s)
The Journal of Organic Chemistry, 48, p. 2424, 1983 DOI: 10.1021/jo00162a028
Properties of Boc-5-aminopentanoic acid
| Melting point: | 48-52 °C(lit.) |
| Boiling point: | 160-168 °C0.8 mm Hg(lit.) |
| Density | 1.1518 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 4.72±0.10(Predicted) |
| color | Off-white |
| BRN | 2048862 |
| CAS DataBase Reference | 27219-07-4(CAS DataBase Reference) |
Safety information for Boc-5-aminopentanoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Boc-5-aminopentanoic acid
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product: 27219-07-4 N-tert -Butoxycarbonyl-5-aminopentanoic acid 98%
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