BMS813160
- CAS NO.：1286279-29-5
- Empirical Formula: C25H40N8O2
- Molecular Weight: 484.64
- MDL number: MFCD31540731
- Update Date: 2024-11-09 21:40:10
What is BMS813160?
Description
BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.
The Uses of BMS813160
BMS-813160, a dual CCR2/CCR5 chemokine antagonist.
Properties of BMS813160
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM) Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM) |
| form | A crystalline solid |
| pka | 15.46±0.60(Predicted) |
| color | White to off-white |
Safety information for BMS813160
Computed Descriptors for BMS813160
New Products
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