PD-L1 inhibitor 1
- CAS NO.:1675203-84-5
- Empirical Formula: C25H29N3O3
- Molecular Weight: 419.52
- MDL number: MFCD29905455
- Update Date: 2024-11-18 17:01:59
What is PD-L1 inhibitor 1?
Description
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM.
The Uses of PD-L1 inhibitor 1
BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.
References
1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323 2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857
Properties of PD-L1 inhibitor 1
Boiling point: | 611.4±55.0 °C(Predicted) |
Density | 1.133±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml) |
form | solid |
pka | 16.06±0.46(Predicted) |
color | White |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Safety information for PD-L1 inhibitor 1
Computed Descriptors for PD-L1 inhibitor 1
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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