PD-L1 inhibitor 1

CAS NO.：1675203-84-5
Empirical Formula: C25H29N3O3
Molecular Weight: 419.52
MDL number: MFCD29905455
Update Date: 2024-11-15 19:19:13

What is PD-L1 inhibitor 1?

Description

The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC₅₀ value of 18 nM.

The Uses of PD-L1 inhibitor 1

BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.

References

1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323 2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857

Properties of PD-L1 inhibitor 1

Boiling point:	611.4±55.0 °C(Predicted)
Density	1.133±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form	solid
pka	16.06±0.46(Predicted)
color	White
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.