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HomeProduct name listBMS-986205

BMS-986205

  • CAS NO.:1923833-60-6
  • Empirical Formula: C24H24ClFN2O
  • Molecular Weight: 410.91
  • MDL number: MFCD31619233
  • Update Date: 2024-11-19 20:33:22
BMS-986205 Structural

What is BMS-986205?

Description

BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.

Biological Activity

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

The Uses of BMS-986205

BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders.

Properties of BMS-986205

Boiling point: 606.8±45.0 °C(Predicted)
Density  1?+-.0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM)
form  Solid
pka 13.80±0.70(Predicted)
color  White to off-white

Safety information for BMS-986205

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BMS-986205

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