BMS-986205

CAS NO.：1923833-60-6
Empirical Formula: C24H24ClFN2O
Molecular Weight: 410.91
MDL number: MFCD31619233
Update Date: 2024-11-01 18:09:03

What is BMS-986205?

Description

BMS-986205, also known as Linrodostat, ONO-7701 and F001287, a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities.

Biological Activity

Linrodostat (BMS-986205, ONO-7701) is an irreversible inhibitor of IDO1 with an IC50 of 1.7 nM. It inhibits kynurenine production with IC50 values of 1.7, 1.1 and > 2000 in human HeLa, HEK293 expressing human IDO-1 and tryptophan-2, 3-dioxygenase cell-based assays.

The Uses of BMS-986205

BMS-986205 is a compound being studied for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders.

Properties of BMS-986205

Boiling point:	606.8±45.0 °C(Predicted)
Density	1?+-.0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM)
form	Solid
pka	13.80±0.70(Predicted)
color	White to off-white

Safety information for BMS-986205

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.