BIS(4-NITROPHENYL) CARBONATE

Synonym(s):4-Nitrophenyl carbonate

CAS NO.：5070-13-3
Empirical Formula: C13H8N2O7
Molecular Weight: 304.21
MDL number: MFCD00007322
EINECS: 225-775-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is BIS(4-NITROPHENYL) CARBONATE?

Chemical properties

white to pale yellow or beige powder

The Uses of BIS(4-NITROPHENYL) CARBONATE

Bis(4-nitrophenyl) carbonate is used as a reagent for preparation of symmetrical and unsymmetrical urea and 4-nitrophenyl esters of N-protected amino acids. It acts as a peptide coupling reagent. It finds application as a reagent for the preparation of carbamate linked cytosines.

Purification Methods

Dissolve the carbonate in CHCl3, wash it with 2N NaOH (3 x) and once with conc HCl, dry (Na2SO4), evaporate and crystallise the residue from toluene (authors say prisms from 15 volumes of *benzene). [Glatthard & Matter Helv Chim Acta 46 795 1963, Beilstein 6 III 820.]

Properties of BIS(4-NITROPHENYL) CARBONATE

Melting point:	136-139 °C(lit.)
Boiling point:	475.9±30.0 °C(Predicted)
Density	1.501±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in chloroform and tetrahydrofuran.
form	Liquid
color	Clear slightly yellow or greenish to brown
Sensitive	Moisture Sensitive
BRN	1892897
CAS DataBase Reference	5070-13-3(CAS DataBase Reference)

Safety information for BIS(4-NITROPHENYL) CARBONATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.