BIOTIN HPDP
- CAS NO.:129179-83-5
- Empirical Formula: C24H37N5O3S3
- Molecular Weight: 539.78
- MDL number: MFCD00078541
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:35
What is BIOTIN HPDP?
Description
Biotin-HPDP is a sulfhydryl-reactive biotinylation reagent that forms a reversible disulfide linkage. It is used to label protein cysteines and other substrates that contain sulfhydryl groups. Biotin-HPDP is also used in the biotin switch technique to tag S-nitrosylated (SNO) proteins, following reduction of SNO groups to thiols. Compounds that are tagged with biotin interact avidly with streptavidin-coupled beads, fluorophores, enzymes, etc. The interaction of biotin-HPDP with substrates containing sulfhydryl groups is easily performed at pH 6.5 to 7.5 in buffers such as PBS. The disulfide linkage that is formed between avidin and substrate can later by cleaved by a reducing agent, like dithiothreitol.
Chemical properties
Pale Yellow Solid
The Uses of BIOTIN HPDP
This compounds reacts specifically with thiol groups.
What are the applications of Application
Biotin HPDP is a fully cleavable, biotinylating reagent that reacts specifically with thiol groups.
Properties of BIOTIN HPDP
Melting point: | 160-163°C |
Boiling point: | 876.0±65.0 °C(Predicted) |
Density | 1.28 |
storage temp. | -20°C Freezer |
solubility | insoluble in H2O; ≥101.4 mg/mL in DMSO; ≥8.29 mg/mL in EtOH with ultrasonic |
pka | 13.90±0.40(Predicted) |
form | powder to crystal |
color | White to Light yellow |
Safety information for BIOTIN HPDP
Computed Descriptors for BIOTIN HPDP
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