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HomeProduct name listD-DESTHIOBIOTIN

D-DESTHIOBIOTIN

Synonym(s):5-Methyl-2-oxo-4-imidazolidinehexanoic acid

  • CAS NO.:533-48-2
  • Empirical Formula: C10H18N2O3
  • Molecular Weight: 214.26
  • MDL number: MFCD00213804
  • EINECS: 208-566-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
D-DESTHIOBIOTIN Structural

What is D-DESTHIOBIOTIN?

The Uses of D-DESTHIOBIOTIN

D-Desthiobiotin is an analogue of Biotin (B389040) that binds less tightly to biotin-binding proteins such as Avidin and is easily displaced by Biotin.

What are the applications of Application

D-Desthiobiotin is a biotin derivative used to label, detect, and isolate proteins in affinity chromatography and protein chromatography.

Definition

ChEBI: (4R,5S)-dethiobiotin is the (4R,5S)-isomer of dethiobiotin. It is a conjugate acid of a (4R,5S)-dethiobiotin(1-). It is an enantiomer of a (4S,5R)-dethiobiotin.

Purification Methods

Dissolve desthiobiotin in 0.5% Na2CO3, filter, acidify with HCl to Congo Red, concentrate to a small volume (2-3 mL) to give fine needles, filter it off and recrystallise it twice from H2O, m 157-158o. It also crystallises from 95% EtOH. The methyl ester crystallises from MeOH and sublimes at 100o/high vacuum, m 69-70o, [] D +2.6o (c 2, CHCl3). [Melville et al. Science 98 497 1943, J Am Chem Soc 66 1422 1944, Beilstein 25 III/IV 1543.]

Properties of D-DESTHIOBIOTIN

Melting point: 156-158°
Boiling point: 354.4°C (rough estimate)
alpha  D21 +10.7° (c = 2)
Density  1.1404 (rough estimate)
refractive index  1.4550 (estimate)
storage temp.  2-8°C
solubility  Aqueous Base (Slightly), DMSO (Slightly)
form  Solid
pka 4.77±0.10(Predicted)
color  White to Off-White

Safety information for D-DESTHIOBIOTIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P330:Rinse mouth.
P363:Wash contaminated clothing before reuse.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P501:Dispose of contents/container to..…

Computed Descriptors for D-DESTHIOBIOTIN

InChIKey AUTOLBMXDDTRRT-UHFFFAOYSA-N

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