D-DESTHIOBIOTIN
Synonym(s):5-Methyl-2-oxo-4-imidazolidinehexanoic acid
- CAS NO.：533-48-2
- Empirical Formula: C10H18N2O3
- Molecular Weight: 214.26
- MDL number: MFCD00213804
- EINECS: 208-566-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:09
What is D-DESTHIOBIOTIN?
The Uses of D-DESTHIOBIOTIN
D-Desthiobiotin is an analogue of Biotin (B389040) that binds less tightly to biotin-binding proteins such as Avidin and is easily displaced by Biotin.
What are the applications of Application
D-Desthiobiotin is a biotin derivative used to label, detect, and isolate proteins in affinity chromatography and protein chromatography.
Definition
ChEBI: (4R,5S)-dethiobiotin is the (4R,5S)-isomer of dethiobiotin. It is a conjugate acid of a (4R,5S)-dethiobiotin(1-). It is an enantiomer of a (4S,5R)-dethiobiotin.
Purification Methods
Dissolve desthiobiotin in 0.5% Na2CO3, filter, acidify with HCl to Congo Red, concentrate to a small volume (2-3 mL) to give fine needles, filter it off and recrystallise it twice from H2O, m 157-158o. It also crystallises from 95% EtOH. The methyl ester crystallises from MeOH and sublimes at 100o/high vacuum, m 69-70o, [] D +2.6o (c 2, CHCl3). [Melville et al. Science 98 497 1943, J Am Chem Soc 66 1422 1944, Beilstein 25 III/IV 1543.]
Properties of D-DESTHIOBIOTIN
| Melting point: | 156-158° |
| Boiling point: | 354.4°C (rough estimate) |
| alpha | D21 +10.7° (c = 2) |
| Density | 1.1404 (rough estimate) |
| refractive index | 1.4550 (estimate) |
| storage temp. | 2-8°C |
| solubility | Aqueous Base (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 4.77±0.10(Predicted) |
| color | White to Off-White |
Safety information for D-DESTHIOBIOTIN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P363:Wash contaminated clothing before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..… |
Computed Descriptors for D-DESTHIOBIOTIN
| InChIKey | AUTOLBMXDDTRRT-UHFFFAOYSA-N |
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