Betulinic acid
Synonym(s):3β-Hydroxy-20(29)-lupaene-28-oic acid;Lupatic acid;Mairin
- CAS NO.：472-15-1
- Empirical Formula: C30H48O3
- Molecular Weight: 456.71
- MDL number: MFCD00009619
- EINECS: 207-448-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-03 18:42:19
What is Betulinic acid ?
Description
Betulinic acid (472-15-1) is a natural Lupane triterpenoid from white birch tree (Betula pubescens). Induces apoptosis in a variety of cell lines.1 Induces mitochondrial permeability transition pore opening.2 ?Acts as a chemosensitizer for anticancer drug treatment in chemoresistant colon cancer cell lines.3 Cell permeable.
Description
Betulinic acid is a naturally-occurring triterpene found in the bark of the white birch tree. Research has found betulinic acid to be particularly useful against melanoma, a dangerous form of skin cancer, by targeting tumors without destroying healthy cells.
The Uses of Betulinic acid
Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activati ng the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity
Background
Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome.
What are the applications of Application
Betulinic Acid is a cytotoxic, cell apoptosis causing agent that upregulates caspase-8
Metabolism
Not Available
Properties of Betulinic acid
| Melting point: | 295-298 °C (dec.) (lit.) |
| Boiling point: | 550.0±33.0 °C(Predicted) |
| Density | 1.065±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | neat |
| color | White or off-white |
Safety information for Betulinic acid
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Betulinic acid
| InChIKey | QGJZLNKBHJESQX-FZFNOLFKSA-N |
Abamectin manufacturer
Dr. ASCRO Bio Sciences Private Limited
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