beta-Cyclodextrin methyl ethers
Synonym(s):Methyl-beta-cyclodextrin;MβCD;MEBCD;Methyl-β-CD;Cavasol W7 M
- CAS NO.:128446-36-6
- Empirical Formula: C54H94O35
- Molecular Weight: 1303.3
- MDL number: MFCD00074980
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-12 15:22:20
What is beta-Cyclodextrin methyl ethers?
Description
Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.
Chemical properties
White powder
The Uses of beta-Cyclodextrin methyl ethers
Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.
The Uses of beta-Cyclodextrin methyl ethers
substrate for laminarinase and other glucanases
The Uses of beta-Cyclodextrin methyl ethers
Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts.
What are the applications of Application
Methyl-β-cyclodextrin is a randomly methylated form of β-cyclodextrin, a reagent used to increase the solubility of non-polar substances.
General Description
Methyl-β-cyclodextrin is a small cyclic heptasaccharide.
Biochem/physiol Actions
Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.
Properties of beta-Cyclodextrin methyl ethers
Melting point: | 180-182 °C(lit.) |
alpha | +159°(25℃, c=1, H2O) |
Flash point: | 187 °C |
storage temp. | room temp |
solubility | H2O: soluble50mg/mL |
form | powder |
color | White to off-white |
optical activity | [α]25/D +159°, c = 1 in H2O |
Water Solubility | Soluble in water |
EPA Substance Registry System | .beta.-Cyclodextrin, methyl ethers (128446-36-6) |
Safety information for beta-Cyclodextrin methyl ethers
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P363:Wash contaminated clothing before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. P403:Store in a well-ventilated place. |
Computed Descriptors for beta-Cyclodextrin methyl ethers
InChIKey | YZOUYRAONFXZSI-SBHWVFSVSA-N |
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