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HomeProduct name listbeta-Cyclodextrin methyl ethers

beta-Cyclodextrin methyl ethers

Synonym(s):Methyl-beta-cyclodextrin;MβCD;MEBCD;Methyl-β-CD;Cavasol W7 M

  • CAS NO.:128446-36-6
  • Empirical Formula: C54H94O35
  • Molecular Weight: 1303.3
  • MDL number: MFCD00074980
  • EINECS: 1308068-626-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-12 15:22:20
beta-Cyclodextrin methyl ethers Structural

What is beta-Cyclodextrin methyl ethers?

Description

Methyl-β-cyclodextrin is a randomly methylated form of the cyclic oligosaccharide β-cyclodextrin . Methyl-β-cyclodextrin contains seven D-(+)-glucopyranose units that contain randomized hydrogen or methyl groups. Methyl-β-cyclodextrin has been used to improve the aqueous solubility of various compounds and to extract cholesterol from lipid membranes. Methyl-β-cyclodextrin (5 mM) reduces α-synuclein levels in the membrane and detergent-insoluble fractions from B103 neuroblastoma cells transfected with human α-synuclein. It also reduces α-synuclein levels in mouse brain in a transgenic model of α-synucleinopathy.

Chemical properties

White powder

The Uses of beta-Cyclodextrin methyl ethers

Methyl-β-cyclodextrin is a cholesterol-removing agent mainly used for lipid raft disruption. It may also be used for detergent removal from protein-lipid-detergent ternary mixture to produce 2D membrane protein crystals due to its high solubility and affinity for detergents generally used in membrane protein chemistry.

The Uses of beta-Cyclodextrin methyl ethers

substrate for laminarinase and other glucanases

The Uses of beta-Cyclodextrin methyl ethers

Cavity size is the major determinant as to which cyclodextrin is used in complexation. The cavity diameter of β-cyclodextrins or β-glucopyranose unit compounds is well-suited for use with molecules the size of hormones, vitamins and many compounds frequently used in tissue and cell culture applications. For this reason, β-cyclodextrin is most commonly used as a complexing agent. It is used to increase the solubility of non-polar substances such as fatty acids, lipids, vitamins and cholesterol for use in cell culture applications. Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and is employed to remove lipid rafts.

What are the applications of Application

Methyl-β-cyclodextrin is a randomly methylated form of β-cyclodextrin, a reagent used to increase the solubility of non-polar substances.

General Description

Methyl-β-cyclodextrin is a small cyclic heptasaccharide.

Biochem/physiol Actions

Methyl-β-cyclodextrin participates in increasing the permeability of cells. It also plays a role in depolymerizing the actin cytoskeleton in cells. Methyl-β-cyclodextrin is involved in attracting cholesterol from the plasma. It participates in activating extracellular receptor kinase in certain cells.

Properties of beta-Cyclodextrin methyl ethers

Melting point: 180-182 °C(lit.)
alpha  +159°(25℃, c=1, H2O)
Flash point: 187 °C
storage temp.  room temp
solubility  H2O: soluble50mg/mL
form  powder
color  White to off-white
optical activity [α]25/D +159°, c = 1 in H2O
Water Solubility  Soluble in water
EPA Substance Registry System .beta.-Cyclodextrin, methyl ethers (128446-36-6)

Safety information for beta-Cyclodextrin methyl ethers

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P272:Contaminated work clothing should not be allowed out of the workplace.
P363:Wash contaminated clothing before reuse.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P403:Store in a well-ventilated place.

Computed Descriptors for beta-Cyclodextrin methyl ethers

InChIKey YZOUYRAONFXZSI-SBHWVFSVSA-N

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