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HomeProduct name listBenzydamine hydrochloride

Benzydamine hydrochloride

Synonym(s):1-Benzyl-3-(3-[dimethylamino]propoxy)-1H-indazole

  • CAS NO.:132-69-4
  • Empirical Formula: C19H23N3O.ClH
  • Molecular Weight: 345.87
  • MDL number: MFCD00078957
  • EINECS: 205-076-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Benzydamine hydrochloride Structural

What is Benzydamine hydrochloride?

Description

Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.

Chemical properties

Off-White Solid

Originator

Tantum,Angelini

The Uses of Benzydamine hydrochloride

Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.

The Uses of Benzydamine hydrochloride

A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.

The Uses of Benzydamine hydrochloride

anticholinergic

The Uses of Benzydamine hydrochloride

A nonsteroidal anti-inflammatory with local anesthetic properties.

What are the applications of Application

Benzydamine Hydrochloride is a nonsteroidal anti-inflammatory with local anesthetic properties

Definition

ChEBI: Benzydamine hydrochloride is a member of indazoles.

Manufacturing Process

To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120 ml of concentrated hydrochloric acid at 25°C was added concentrated solution of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in 1.5 L of water. To this solution under nitrogen was added 400 g of sodium bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The obtained solid product was dissolved in water and then to the solution was added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino) propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.

brand name

Tantum (Angelini Francesco, Italy).

Therapeutic Function

Analgesic, Antiinflammatory, Antipyretic

Contact allergens

It is a nonsteroidal anti-inflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer.

Side Effects

The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental animal reproductive effects. An eye irritant. A nonsteroidal antiinflammatory analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Properties of Benzydamine hydrochloride

Melting point: 147-153°C
storage temp.  Inert atmosphere,2-8°C
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form  Solid
form  neat
color  White to Off-White
Water Solubility  Soluble in water, ethanol, chloroform, n-butanol or DMSO /n
Merck  14,1122
CAS DataBase Reference 132-69-4(CAS DataBase Reference)

Safety information for Benzydamine hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Benzydamine hydrochloride

InChIKey HNNIWKQLJSNAEQ-UHFFFAOYSA-N

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