Benzydamine hydrochloride
Synonym(s):1-Benzyl-3-(3-[dimethylamino]propoxy)-1H-indazole
- CAS NO.:132-69-4
- Empirical Formula: C19H23N3O.ClH
- Molecular Weight: 345.87
- MDL number: MFCD00078957
- EINECS: 205-076-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Benzydamine hydrochloride?
Description
Benzydamine hydrochloride is a non-steroidal antiinflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer and caused occupational contact dermatitis in a nurse.
Chemical properties
Off-White Solid
Originator
Tantum,Angelini
The Uses of Benzydamine hydrochloride
Benzydamine hydrochloride is an anti-in-flammatory drug used extensively in Europe and recently introduced in Canada to help re duce painful mucositis. Benzydamine provides short-term topical anesthesia and extended pain relief apparently through its anti-inflammatory properties. Studies have shown it to be effective in a range of painful conditions, including aphthous ulceration, chemotherapy-induced mucositis, and radiation-induced mucositis.
The Uses of Benzydamine hydrochloride
A nonsteroidal anti-inflammatory drug with local anaesthetic, analgesic and antipyretic properties.
The Uses of Benzydamine hydrochloride
anticholinergic
The Uses of Benzydamine hydrochloride
A nonsteroidal anti-inflammatory with local anesthetic properties.
What are the applications of Application
Benzydamine Hydrochloride is a nonsteroidal anti-inflammatory with local anesthetic properties
Definition
ChEBI: Benzydamine hydrochloride is a member of indazoles.
Manufacturing Process
To a solution of 175 g of anthranilic acid methyl ester in 2 L of water and 120
ml of concentrated hydrochloric acid at 25°C was added concentrated solution
of 80 g sodium nitrite. The product was dissolved in solution of 500 g NaOH in
1.5 L of water. To this solution under nitrogen was added 400 g of sodium
bisulfite. The mixture was stirred for 6 hours at 75°C under nitrogen. The
obtained solid product was dissolved in water and then to the solution was
added 750 ml glacial acetic acid. The yield of 1-benzyl-3-(3-(dimethylamino)
propoxy)-1H-indazole 70%, M.P. 154-156°C.
In practice it is usually used as monohydrochloride salt.
brand name
Tantum (Angelini Francesco, Italy).
Therapeutic Function
Analgesic, Antiinflammatory, Antipyretic
Contact allergens
It is a nonsteroidal anti-inflammatory drug used both topically and systemically. It has been reported as a sensitizer and a photosensitizer.
Side Effects
The major side effects of benzydamine hydrochloride are oral numbness (reported prevalence: 10 percent), and oral burning/stinging (reported prevalence: 8 percent). Oral discomfort appears to be more of a problem in patients with extensive ulceration/infammation. The oral discomfort can sometimes be improved by diluting the benzydamine hydrochloride with an equal volume of water.It is thought that benzydamine hydrochloride does not precipitate peptic ulceration.
Safety Profile
Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental animal reproductive effects. An eye irritant. A nonsteroidal antiinflammatory analgesic. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Properties of Benzydamine hydrochloride
Melting point: | 147-153°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
form | neat |
color | White to Off-White |
Water Solubility | Soluble in water, ethanol, chloroform, n-butanol or DMSO
/n |
Merck | 14,1122 |
CAS DataBase Reference | 132-69-4(CAS DataBase Reference) |
Safety information for Benzydamine hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Benzydamine hydrochloride
InChIKey | HNNIWKQLJSNAEQ-UHFFFAOYSA-N |
Abamectin manufacturer
Centaur Pharmaceuticals Pvt Ltd
Rivashaa Agrotech Biopharma Pvt. Ltd.
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