BENZO(C)PHENANTHRENE

CAS NO.：195-19-7
Empirical Formula: C18H12
Molecular Weight: 228.29
MDL number: MFCD00019126
EINECS: 205-896-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is BENZO(C)PHENANTHRENE?

Chemical properties

Yellow Solid

The Uses of BENZO(C)PHENANTHRENE

A PAH metabolite having a toxic effect on fish bone metabolite. Also, it is used as a marker of the carcinogenic potency of the polycyclic aromatic hydrocarbons (PAH) mixture. A genotoxic agent.

Definition

ChEBI: An ortho-fused polycyclic arene resulting from the symmetrical fusion of the C1-C2 bonds of two naphthalene units.

Safety Profile

Questionable carcinogen withexperimental tumorigenic data. Mutation data reported.When heated to decomposition it emits acrid and irritatingfumes.

Carcinogenicity

Dermal administration (initiation– promotion protocols) to mice showed benzo[c]phenanthrene was a tumor-initiating agent. Repeated dermal administration in mice or subcutaneous injection into mice or rats gave results considered to be inadequate for evaluation (3). Intraperitoneal injection of benzo[c]phenanthrene into infant mice resulted in a substantial induction of lung tumors. Seven suspected activated metabolites were also active, as well as in two-stage mouse carcinogenesis assays.

Purification Methods

Crystallise benzo[c]phenanthrene from EtOH, pet ether, or EtOH/Me2CO. [Beilstein 5 III 2378, 5 IV 2552.]

Properties of BENZO(C)PHENANTHRENE

Melting point:	158-160℃
Boiling point:	305.1°C (rough estimate)
Density	1.1209 (estimate)
refractive index	1.5500 (estimate)
storage temp.	Sealed in dry,2-8°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly)
form	neat
color	Needles from EtOH or pet ether
BRN	1909296
Stability:	Light Sensitive
IARC	2B (Vol. 92, Sup 7) 2010
EPA Substance Registry System	Benzo[c]phenanthrene (195-19-7)

Safety information for BENZO(C)PHENANTHRENE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.