Methyl 4-aminobenzoate

CAS NO.：619-45-4
Empirical Formula: C8H9NO2
Molecular Weight: 151.16
MDL number: MFCD00007891
EINECS: 210-598-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-30 18:52:02

What is Methyl 4-aminobenzoate?

Chemical properties

white to beige crystals or crystalline powder

The Uses of Methyl 4-aminobenzoate

Methyl 4-aminobenzoate is used in the synthesis of guanidine alkaloids, (±)-martinelline and (±)-martinellic acid by a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline. It is also used in organic synthesis and acts as a dye intermediate. Further, it is used to prepare 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-benzoic acid methyl ester by reacting with 2-acetylamino-benzoic acid.

The Uses of Methyl 4-aminobenzoate

Methyl 4-aminobenzoate was used in the syntheses of guanidine alkaloids, (±)-martinelline and (±)-martinellic acid by a protic acid catalyzed hetero Diels-Alder coupling reaction with N-Cbz 2-pyrroline.

Synthesis Reference(s)

Synthetic Communications, 26, p. 973, 1996 DOI: 10.1080/00397919608003701
Synthesis, p. 23, 1978

General Description

The catalytic oxidation of methyl 4-aminobenzoate by hydrogen peroxide was studied.

Properties of Methyl 4-aminobenzoate

Melting point:	110-111 °C (lit.)
Boiling point:	273.17°C (rough estimate)
Density	1.2023 (rough estimate)
refractive index	1.5810 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	3.82g/l
pka	pK1:2.38(＋1) (25°C)
form	Crystals or Crystalline Powder
color	White to beige
Water Solubility	Soluble in alcohol and ether. Slightly soluble in water.
BRN	775913
CAS DataBase Reference	619-45-4(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 4-amino-, methyl ester(619-45-4)
EPA Substance Registry System	Benzoic acid, 4-amino-, methyl ester (619-45-4)

Safety information for Methyl 4-aminobenzoate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.